WL 19

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585413

CAS#: 114785-18-1

Description: WL 19 is an angiotensin II type 2 receptor antagonist.

Chemical Structure

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WL 19
CAS# 114785-18-1
Instruction

Theoretical Analysis

MedKoo Cat#: 585413
Name: WL 19
CAS#: 114785-18-1
Chemical Formula: C30H29N3O4
Exact Mass: 495.22
Molecular Weight: 495.579
Elemental Analysis: C, 72.71; H, 5.90; N, 8.48; O, 12.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WL 19; WL19; WL-19; PD 121981; PD121981; PD-121981

IUPAC/Chemical Name: 5-(2,2-diphenylacetyl)-4-[(4-methoxy-3-methylphenyl)methyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid

InChi Key: UKTWVUDMCNZPTF-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H29N3O4/c1-19-15-20(13-14-26(19)37-2)16-24-28-23(31-18-32-28)17-25(30(35)36)33(24)29(34)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-15,18,24-25,27H,16-17H2,1-2H3,(H,31,32)(H,35,36)

SMILES Code: O=C(C1CC2=C(N=CN2)C(CC3=CC=C(OC)C(C)=C3)N1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 495.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drejer D, Béji S, Oezeke R, Nielsen AM, Høyer S, Bjerklund Johansen TE, Lam GW, Jensen JB. Comparison of White Light, Photodynamic Diagnosis, and Narrow-band Imaging in Detection of Carcinoma In Situ or Flat Dysplasia at Transurethral Resection of the Bladder: the DaBlaCa-8 Study. Urology. 2017 Apr;102:138-142. doi: 10.1016/j.urology.2016.11.032. Epub 2016 Nov 25. PubMed PMID: 27894979.

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7: Smith MT, Lau T, Wallace VC, Wyse BD, Rice AS. Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behav Pharmacol. 2014 Apr;25(2):137-46. doi: 10.1097/FBP.0000000000000025. PubMed PMID: 24525712.

8: Edwards RM, Stack EJ, Weidley EF, Aiyar N, Keenan RM, Hill DT, Weinstock J. Characterization of renal angiotensin II receptors using subtype selective antagonists. J Pharmacol Exp Ther. 1992 Mar;260(3):933-8. PubMed PMID: 1545405.

9: Siegl PK, Chang RS, Mantlo NB, Chakravarty PK, Ondeyka DL, Greenlee WJ, Patchett AA, Sweet CS, Lotti VJ. In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist. J Pharmacol Exp Ther. 1992 Jul;262(1):139-44. PubMed PMID: 1625193.

10: Smith MT, Woodruff TM, Wyse BD, Muralidharan A, Walther T. A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Med. 2013 Oct;14(10):1557-68. doi: 10.1111/pme.12157. Epub 2013 Jun 6. PubMed PMID: 23742186.

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12: Gehlert DR, Gackenheimer SL, Reel JK, Lin HS, Steinberg MI. Non-peptide angiotensin II receptor antagonists discriminate subtypes of 125I-angiotensin II binding sites in the rat brain. Eur J Pharmacol. 1990 Oct 2;187(1):123-6. PubMed PMID: 2272349.

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14: Chang RS, Lotti VJ. Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency. Life Sci. 1991;49(20):1485-90. PubMed PMID: 1943452.

15: Chang RS, Lotti VJ. Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Mol Pharmacol. 1990 Mar;37(3):347-51. PubMed PMID: 2314387.

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17: Edwards RM, Stack EJ. Angiotensin II inhibits glomerular adenylate cyclase via the angiotensin II receptor subtype 1 (AT1). J Pharmacol Exp Ther. 1993 Aug;266(2):506-10. PubMed PMID: 8394907.

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