WF 3681

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585409

CAS#: 105364-56-5

Description: WF 3681 is an aldose reductase inhibitor. Its derivative, FR-62765, helped prevent accumulation of sorbitol in the sciatic nerve and the reduction of motor nerve conduction velocity in the tail of rats.


Chemical Structure

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WF 3681
CAS# 105364-56-5

Theoretical Analysis

MedKoo Cat#: 585409
Name: WF 3681
CAS#: 105364-56-5
Chemical Formula: C13H12O5
Exact Mass: 248.07
Molecular Weight: 248.234
Elemental Analysis: C, 62.90; H, 4.87; O, 32.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: WF 3681; WF3681; WF-3681

IUPAC/Chemical Name: 3-(4-hydroxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoic acid

InChi Key: PPZVSYXNLXFYAD-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12O5/c14-10(15)7-6-9-11(12(16)13(17)18-9)8-4-2-1-3-5-8/h1-5,9,16H,6-7H2,(H,14,15)

SMILES Code: O=C(O)CCC(C(C1=CC=CC=C1)=C2O)OC2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nishikawa M, Yoshida K, Okamoto M, Itoh Y, Kohsaka M. Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo). 1991 Apr;44(4):441-4. PubMed PMID: 1903376.

2: Kissinger CR, Turley S, Clark JI. Structure of WF-3681, 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid. Acta Crystallogr C. 1988 Mar 15;44 ( Pt 3):512-4. PubMed PMID: 3152105.

3: Nishikawa M, Tsurumi Y, Namiki T, Yoshida K, Okuhara M. Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization. J Antibiot (Tokyo). 1987 Oct;40(10):1394-9. PubMed PMID: 3119547.

4: Namiki T, Nishikawa M, Itoh Y, Uchida I, Hashimoto M. Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis. J Antibiot (Tokyo). 1987 Oct;40(10):1400-7. PubMed PMID: 3119548.

5: Nishikawa M, Yoshida K, Okamoto M, Kohsaka M. Studies on WE-3681, a novel aldose reductase inhibitor. III. Effects of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats. J Antibiot (Tokyo). 1990 Sep;43(9):1186-8. PubMed PMID: 2120169.

6: Namiki T, Baba Y, Suzuki Y, Nishikawa M, Sawada K, Itoh Y, Oku T, Kitaura Y, Hashimoto M. Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor. Chem Pharm Bull (Tokyo). 1988 Apr;36(4):1404-14. PubMed PMID: 3138031.