Abacavir carboxylate

Abacavir carboxylate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574219

CAS#: 384380-52-3 (caeboxylate)

Description: Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir. It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

Chemical Structure

Abacavir carboxylate

CAS# 384380-52-3 (caeboxylate)

Instruction

Theoretical Analysis

MedKoo Cat#: 574219
Name: Abacavir carboxylate
CAS#: 384380-52-3 (caeboxylate)
Chemical Formula: C14H16N6O2
Exact Mass: 300.1335
Molecular Weight: 300.32
Elemental Analysis: C, 55.99; H, 5.37; N, 27.98; O, 10.65

Price and Availability

Size	Price	Availability	Quantity
1.0mg	USD 480.0	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Abacavir carboxylate

IUPAC/Chemical Name: (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic acid

InChi Key: OCSMNHMMTKMVCP-APPZFPTMSA-N

InChi Code: InChI=1S/C14H16N6O2/c15-14-18-11(17-8-2-3-8)10-12(19-14)20(6-16-10)9-4-1-7(5-9)13(21)22/h1,4,6-9H,2-3,5H2,(H,21,22)(H3,15,17,18,19)/t7-,9+/m1/s1

SMILES Code: NC1=NC(N([C@H]2C=C[C@@H](C(O)=O)C2)C=N3)=C3C(NC4CC4)=N1

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Instruction:

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 300.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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1. Martin, M.A., and Kroetz, D.L. Abacavir pharmacogenetics--from initial reports to standard of care. Pharmacotherapy 33(7), 765-775 (2013).

2. Charneira, C., Godinho, A.L.A., Oliveira, M.C., et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem. Res. Toxicol. 24(12), 2129-21241 (2011).

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1.0mg / USD 480.0