UCM-05194

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MedKoo CAT#: 555707

CAS#: 2411412-36-5 (S-isomer)

Description: UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist described so far (Emax = 118%, EC50 = 0.24 μM, KD = 19.6 nM; inactive at autotaxin and LPA2-6 receptors).


Price and Availability

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Pricing updated 2020-10-31. Prices are subject to change without notice.

UCM-05194 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555707
Name: UCM-05194
CAS#: 2411412-36-5 (S-isomer)
Chemical Formula: C19H30BrO6P
Exact Mass: 464.0963
Molecular Weight: 465.3208
Elemental Analysis: C, 49.04; H, 6.50; Br, 17.17; O, 20.63; P, 6.66


Related CAS #: 2400858-34-4 (R-isomer)   2411412-36-5 (S-isomer)   UCM-05194 sodium    

Synonym: UCM-05194; UCM 05194; UCM05194;

IUPAC/Chemical Name: (2S)-1-Bromo-3-(phosphonooxy)propan-2-yl 10-Phenyldecanoate

InChi Key: IHTMTVSBHMPLJC-GOSISDBHSA-N

InChi Code: InChI=1S/C19H30BrO6P/c20-15-18(16-25-27(22,23)24)26-19(21)14-10-5-3-1-2-4-7-11-17-12-8-6-9-13-17/h6,8-9,12-13,18H,1-5,7,10-11,14-16H2,(H2,22,23,24)/t18-/m1/s1

SMILES Code: O=C(O[C@@H](COP(O)(O)=O)CBr)CCCCCCCCCC1=CC=CC=C1


Technical Data

Appearance:
liquid / sticky solid

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Neuropathic pain (NP) is a complex chronic pain state with a prevalence of almost 10% in the general population. Pharmacological options for NP are limited and weakly effective, so there is a need to develop more efficacious NP attenuating drugs. Activation of the type 1 lysophosphatidic acid (LPA1) receptor is a crucial factor in the initiation of NP.


References

1: González-Gil I, Zian D, Vázquez-Villa H, Hernández-Torres G, Martínez RF,
Khiar-Fernández N, Rivera R, Kihara Y, Devesa I, Mathivanan S, Del Valle CR,
Zambrana-Infantes E, Puigdomenech M, Cincilla G, Sanchez-Martinez M, Rodríguez de
Fonseca F, Ferrer-Montiel AV, Chun J, López-Vales R, López-Rodríguez ML,
Ortega-Gutiérrez S. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor
(LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration. J Med Chem.
2019 Dec 16. doi: 10.1021/acs.jmedchem.9b01287. [Epub ahead of print] PubMed
PMID: 31790581.