Iloperidone metabolite P88
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MedKoo CAT#: 574203

CAS#: 133454-55-4

Description: Iloperidone metabolite P88 is an active metabolite of the atypical antipsychotic iloperidone. It binds to the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, and 5-HT2C, α2b- and α2c-adrenergic, and dopamine D1, D2A, and D4 receptors.


Chemical Structure

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Iloperidone metabolite P88
CAS# 133454-55-4

Theoretical Analysis

MedKoo Cat#: 574203
Name: Iloperidone metabolite P88
CAS#: 133454-55-4
Chemical Formula: C24H29FN2O4
Exact Mass: 428.2111
Molecular Weight: 428.5
Elemental Analysis: C, 67.27; H, 6.82; F, 4.43; N, 6.54; O, 14.93

Price and Availability

Size Price Availability Quantity
10.0mg USD 290.0 2 Weeks
25.0mg USD 440.0 2 Weeks
50.0mg USD 720.0 2 Weeks
100.0mg USD 1350.0 2 Weeks
250.0mg USD 2000.0 2 Weeks
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Synonym: Iloperidone metabolite P88, P88-8991

IUPAC/Chemical Name: 4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxy-α-methyl-benzenemethanol

InChi Key: SBKZGLWZGZQVHA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-17,28H,3,8-13H2,1-2H3

SMILES Code: OC(C)C1=CC=C(OCCCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(OC)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 428.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Subramanian, N., and Kalkman, H.O. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Prog. Neuropsychopharmacol. Biol. Psychiatry 26(3), 553-560 (2002).

2. Jia, M., Li, J., He, X., et al. Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 928, 52-57 (2013).