Tanshinone I
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MedKoo CAT#: 574202

CAS#: 568-73-0

Description: Tanshinone I is a diterpene with anticancer, antidiabetic, and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity and inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells. It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia. It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function.

Chemical Structure

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Tanshinone I
CAS# 568-73-0
Instruction

Theoretical Analysis

MedKoo Cat#: 574202
Name: Tanshinone I
CAS#: 568-73-0
Chemical Formula: C18H12O3
Exact Mass: 276.08
Molecular Weight: 276.290
Elemental Analysis: C, 78.25; H, 4.38; O, 17.37

Price and Availability

Size Price Availability Quantity
5mg USD 225
10mg USD 380
25mg USD 655
50mg USD 1200
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Synonym: Tanshinone I, Tanshinone A

IUPAC/Chemical Name: 1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione

InChi Key: AIGAZQPHXLWMOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

SMILES Code: O=C(C1=C2C(C(C)=CC=C2)=CC=C1C3=C4C(C)=CO3)C4=O

Appearance: A crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yang, L., Ding, G., Lin, H., et al. Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. PLoS One 8(11), e80464 (2013).

2. Tian, Q.-T., Ding, C.-Y., Song, S.-S., et al. New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis. Biochem. Pharmacol. 156, 255-264 (2018).

3. Yan, Y., Su, W., Zeng, S., et al. Effect and mechanism of tanshinone I on the radiosensitivity of lung cancer cells. Mol. Pharm. 15(11), 4843-4853 (2018).

4. Wang, S., Jing, H., Yang, H., et al. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson’s disease. J. Ethnaopharmacol. 164, 247-255 (2015).

5. Wei, Y., Gao, J., Qin, L., et al. Tanshinone I alleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway. Biomed. Pharmacother. 93, 352-356 (2017).