Nybomycin
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MedKoo CAT#: 574183

CAS#: 30408-30-1

Description: Nybomycin is a fungal metabolite with antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae. Nybomycin is also active against M. tuberculosis and M. bovis.

Chemical Structure

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Nybomycin
CAS# 30408-30-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574183
Name: Nybomycin
CAS#: 30408-30-1
Chemical Formula: C16H14N2O4
Exact Mass: 298.10
Molecular Weight: 298.298
Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45

Price and Availability

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2mg USD 1250 2 Weeks
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Synonym: NSC 613948, Nybomycin

IUPAC/Chemical Name: 8-(hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione

InChi Key: HKMUGCUFXWTNSP-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2O4/c1-8-3-13(21)18-7-22-16-14-11(5-10(8)15(16)18)9(6-19)4-12(20)17(14)2/h3-5,19H,6-7H2,1-2H3

SMILES Code: CN(C(C=C1CO)=O)C2=C1C=C(C(C)=C3)C4=C2OCN4C3=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
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Biological target: Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties.
In vitro activity: Compound 1 (nybomycin) showed anti-microbial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG with the MIC of 1.0μg/mL under both actively growing aerobic conditions and dormancy inducing hypoxic conditions. Compound 1 is also effective to Mycobacterium tuberculosis including the clinically isolated strains. Reference: Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. https://pubmed.ncbi.nlm.nih.gov/25934225/
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 298.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Shiriaev DI, Sofronova AA, Berdnikovich EA, Lukianov DA, Komarova ES, Marina VI, Zakalyukina YV, Biryukov MV, Maviza TP, Ivanenkov YA, Sergiev PV, Osterman IA, Dontsova OA. Nybomycin inhibits both types of E. coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant. Antimicrob Agents Chemother. 2023 May 1;95(5):e00777-20. doi: 10.1128/AAC.00777-20. Epub 2021 Feb 16. PMID: 33593838; PMCID: PMC8092900. 2. Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17. PMID: 25934225.
In vitro protocol: 1. Shiriaev DI, Sofronova AA, Berdnikovich EA, Lukianov DA, Komarova ES, Marina VI, Zakalyukina YV, Biryukov MV, Maviza TP, Ivanenkov YA, Sergiev PV, Osterman IA, Dontsova OA. Nybomycin inhibits both types of E. coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant. Antimicrob Agents Chemother. 2023 May 1;95(5):e00777-20. doi: 10.1128/AAC.00777-20. Epub 2021 Feb 16. PMID: 33593838; PMCID: PMC8092900. 2. Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17. PMID: 25934225.
In vivo protocol: TBD

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1. Strelitz, F., Flon, H., and Asheshov, I.N. Nybomycin, a new antibiotic with antiphage and antibacterial properties. Proc. Natl. Acad. Sci. U.S.A. 41(9), 620-624 (1955).

2. Arai, M., Kamiya, K., Pruksakorn, P., et al. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg. Med. Chem. 23(13), 3534-3541 (2015).