U 81749

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MedKoo CAT#: 585357

CAS#: 126103-94-4

Description: U 81749 is a peptide that inhibits recombinant HIV-1 protease in vitro and HIV-1 replication in human peripheral blood lymphocytes.


Price and Availability

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Pricing updated 2020-09-28. Prices are subject to change without notice.

U 81749 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585357
Name: U 81749
CAS#: 126103-94-4
Chemical Formula: C33H56N4O4
Exact Mass: 572.4302
Molecular Weight: 572.835
Elemental Analysis: C, 69.19; H, 9.85; N, 9.78; O, 11.17


Synonym: U 81749; U81749; U-81749

IUPAC/Chemical Name: 6-cyclohexyl-5-(3,3-dimethylbutanoylamino)-4-hydroxy-N-[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]-2-propan-2-ylhexanamide

InChi Key: RLQUQIUJPBZNMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H56N4O4/c1-8-23(4)30(32(41)35-21-25-16-12-13-17-34-25)37-31(40)26(22(2)3)19-28(38)27(18-24-14-10-9-11-15-24)36-29(39)20-33(5,6)7/h12-13,16-17,22-24,26-28,30,38H,8-11,14-15,18-21H2,1-7H3,(H,35,41)(H,36,39)(H,37,40)

SMILES Code: O=C(NC(C(C)CC)C(NCC1=NC=CC=C1)=O)C(C(C)C)CC(O)C(NC(CC(C)(C)C)=O)CC2CCCCC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Uhl D. [Therapeutic drugs--rarely causal therapy]. Med Monatsschr Pharm. 1990 May;13(5):129. German. PubMed PMID: 2192241.

2: A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Dis Markers. 1990 May-Jun;8(3):162-3. PubMed PMID: 2125537.

3: Two more attacks on HIV. Lancet. 1990 Feb 10;335(8685):345. PubMed PMID: 1967781.

4: McQuade TJ, Tomasselli AG, Liu L, Karacostas V, Moss B, Sawyer TK, Heinrikson RL, Tarpley WG. A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science. 1990 Jan 26;247(4941):454-6. PubMed PMID: 2405486.