U 68215

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585349

CAS#: 99570-57-7

Description: U 68215 is a prostacyclin analog that inhibits acid secretion without stimulation gastric emptying.

Chemical Structure

U 68215
CAS# 99570-57-7

Theoretical Analysis

MedKoo Cat#: 585349
Name: U 68215
CAS#: 99570-57-7
Chemical Formula: C24H34O5
Exact Mass: 402.2406
Molecular Weight: 402.531
Elemental Analysis: C, 71.61; H, 8.51; O, 19.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: U 68215; U68215; U-68215

IUPAC/Chemical Name: Acetic acid, ((1-(3-cyclohexyl-3-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1H-benz(f)inden-5-yl)oxy)-, (1R-(1alpha(R*),2beta,3aalpha,9aalpha))-


InChi Code: InChI=1S/C24H34O5/c25-21(15-5-2-1-3-6-15)10-9-18-19-11-16-7-4-8-23(29-14-24(27)28)20(16)12-17(19)13-22(18)26/h4,7-8,15,17-19,21-22,25-26H,1-3,5-6,9-14H2,(H,27,28)/t17-,18+,19-,21?,22+/m1/s1

SMILES Code: O=C(O)COC1=C2C[C@]3([H])C[C@H](O)[C@@H](CCC(C4CCCCC4)O)[C@]3([H])CC2=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.531 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shea-Donohue T, Kandasamy A, Dubois A. Effects of a prostacyclin analog, U-68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. J Pharmacol Exp Ther. 1992 Mar;260(3):1023-7. PubMed PMID: 1545375.

2: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68,215. Prostaglandins. 1985 Oct;30(4):619-49. PubMed PMID: 4081062.

3: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Gastrointestinal properties of U-68,215, a stable prostacyclin analogue. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:641-4. PubMed PMID: 2936188.