U 68215

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MedKoo CAT#: 585349

CAS#: 99570-57-7

Description: U 68215 is a prostacyclin analog that inhibits acid secretion without stimulation gastric emptying.


Price and Availability

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Pricing updated 2020-09-28. Prices are subject to change without notice.

U 68215 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585349
Name: U 68215
CAS#: 99570-57-7
Chemical Formula: C24H34O5
Exact Mass: 402.2406
Molecular Weight: 402.531
Elemental Analysis: C, 71.61; H, 8.51; O, 19.87


Synonym: U 68215; U68215; U-68215

IUPAC/Chemical Name: Acetic acid, ((1-(3-cyclohexyl-3-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1H-benz(f)inden-5-yl)oxy)-, (1R-(1alpha(R*),2beta,3aalpha,9aalpha))-

InChi Key: UVTYVOJZXZTZHN-WGMJQOQFSA-N

InChi Code: InChI=1S/C24H34O5/c25-21(15-5-2-1-3-6-15)10-9-18-19-11-16-7-4-8-23(29-14-24(27)28)20(16)12-17(19)13-22(18)26/h4,7-8,15,17-19,21-22,25-26H,1-3,5-6,9-14H2,(H,27,28)/t17-,18+,19-,21?,22+/m1/s1

SMILES Code: O=C(O)COC1=C2C[C@]3([H])C[C@H](O)[C@@H](CCC(C4CCCCC4)O)[C@]3([H])CC2=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Shea-Donohue T, Kandasamy A, Dubois A. Effects of a prostacyclin analog, U-68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. J Pharmacol Exp Ther. 1992 Mar;260(3):1023-7. PubMed PMID: 1545375.

2: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68,215. Prostaglandins. 1985 Oct;30(4):619-49. PubMed PMID: 4081062.

3: Robert A, Aristoff PA, Wendling MG, Kimball FA, Miller WL Jr, Gorman RR. Gastrointestinal properties of U-68,215, a stable prostacyclin analogue. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:641-4. PubMed PMID: 2936188.