WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 471037
Description: MB-0223 is a novel potent and selective STING agonist.
MedKoo Cat#: 471037
Chemical Formula: C26H27N5OS
Exact Mass: 457.1936
Molecular Weight: 457.6
Elemental Analysis: C, 68.24; H, 5.95; N, 15.30; O, 3.50; S, 7.01
Synonym: MB-0223, MB 0223, MB0223
IUPAC/Chemical Name: 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
InChi Key: SWLKFZCOJAYAMJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H27N5OS/c1-19-14-24(25(32)28-22-9-7-20(8-10-22)21-6-5-11-27-15-21)31(16-19)17-23-18-33-26(29-23)30-12-3-2-4-13-30/h5-11,14-16,18H,2-4,12-13,17H2,1H3,(H,28,32)
SMILES Code: O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 457.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Mallat A. et al.; Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1; Biochem Biophys Res Commun. 2018 May 15;499(3):556-562. doi: 10.1016/j.bbrc.2018.03.189. Epub 2018 Apr 4.