WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 471036
CAS#: 442665-87-4
Description: ST 045849 is an O-GlcNAc transferase (OGT) inhibitor, it can reduce proliferation and viability of prostate cancer cells in vitro.
MedKoo Cat#: 471036
Name: ST 045849
CAS#: 442665-87-4
Chemical Formula: C23H27ClN2O3S
Exact Mass: 446.1431
Molecular Weight: 446.99
Elemental Analysis: C, 61.80; H, 6.09; Cl, 7.93; N, 6.27; O, 10.74; S, 7.17
Synonym: ST 045849, ST045849, ST-045849
IUPAC/Chemical Name: (Z)-3-(2-(adamantan-1-yl)ethyl)-2-((4-chlorophenyl)imino)-4-oxo-1,3-thiazinane-6-carboxylic acid
InChi Key: HLPZEZRNGAXCJH-LVWGJNHUSA-N
InChi Code: InChI=1S/C23H27ClN2O3S/c24-17-1-3-18(4-2-17)25-22-26(20(27)10-19(30-22)21(28)29)6-5-23-11-14-7-15(12-23)9-16(8-14)13-23/h1-4,14-16,19H,5-13H2,(H,28,29)/b25-22-
SMILES Code: O=C(C(S/C(N1CCC2(C3)CC4CC3CC(C4)C2)=N\C5=CC=C(Cl)C=C5)CC1=O)O
1. Kim G.et al; Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy; Sci Rep. 2017 Sep 11;7(1):11107. doi: 10.1038/s41598-017-11655-6.
2. Itkonen HM et al.; Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism; Oncotarget. 2016 Mar 15;7(11):12464-76. doi: 10.18632/oncotarget.7039.
3. Kim EJ et al.; Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors; Bioconjug Chem. 2014 Jun 18;25(6):1025-30. doi: 10.1021/bc5001774. Epub 2014 Jun 2
4. Victor V. Lima et al.; O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway; Cardiovasc Res. 2011 Feb 15; 89(3): 614–622.