Imidocarb propionate
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MedKoo CAT#: 574144

CAS#: 55750-06-6 (propionate)

Description: Imidocarb propionate is an antiprotozoal agent that eliminates blood parasites. Formulations containing imidocarb have been used in the veterinary treatment of babesiosis and other protozoal infections.


Chemical Structure

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Imidocarb propionate
CAS# 55750-06-6 (propionate)

Theoretical Analysis

MedKoo Cat#: 574144
Name: Imidocarb propionate
CAS#: 55750-06-6 (propionate)
Chemical Formula: C25H32N6O5
Exact Mass: 0.00
Molecular Weight: 496.568
Elemental Analysis: C, 60.47; H, 6.50; N, 16.92; O, 16.11

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 550 2 Weeks
10g USD 950 2 Weeks
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Related CAS #: 5318-76-3 (HCl)   55750-06-6 (propionate)   27885-92-3 (free base)  

Synonym: Imidocarb propionate

IUPAC/Chemical Name: N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea, dipropanoate

InChi Key: AFGQXWSHYUHHNV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20N6O.2C3H6O2/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18;2*1-2-3(4)5/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26);2*2H2,1H3,(H,4,5)

SMILES Code: O=C(NC1=CC=CC(C2=NCCN2)=C1)NC3=CC(C4=NCCN4)=CC=C3.OC(CC)=O.OC(CC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL.
In vitro activity: TBD
In vivo activity: These findings establish that imidocarb dipropionate treatment clears B. caballi infection with confirmation of lack of transmission risk either by direct blood transfer or a high tick burden. Reference: Antimicrob Agents Chemother. 2009 Oct;53(10):4327-32. https://pubmed.ncbi.nlm.nih.gov/19620328/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 1.0 2.01
DMSO 16.8 33.85
Ethanol 1.0 2.01
PBS (pH 7.2) 10.0 20.14

Preparing Stock Solutions

The following data is based on the product molecular weight 496.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Schwint ON, Ueti MW, Palmer GH, Kappmeyer LS, Hines MT, Cordes RT, Knowles DP, Scoles GA. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrob Agents Chemother. 2009 Oct;53(10):4327-32. doi: 10.1128/AAC.00404-09. Epub 2009 Jul 20. PMID: 19620328; PMCID: PMC2764191.
In vitro protocol: TBD
In vivo protocol: 1. Schwint ON, Ueti MW, Palmer GH, Kappmeyer LS, Hines MT, Cordes RT, Knowles DP, Scoles GA. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrob Agents Chemother. 2009 Oct;53(10):4327-32. doi: 10.1128/AAC.00404-09. Epub 2009 Jul 20. PMID: 19620328; PMCID: PMC2764191.

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1. Mosqueda, J., Olvera-Ramírez, A., Aguilar-Tipacamú, G., et al. Current advances in detection and treatment of babesiosis. Curr. Med. Chem. 19(10), 1504-1518 (2012).

2. Rodriguez, R.I., and Trees, A.J. In vitro responsiveness of Babesia bovis to imidocarb dipropionate and the selection of a drug-adapted line. Vet. Parasitol. 62(1-2), 35-41 (1996).

3. Sevinc, F., Turgut, K., Sevinc, M., et al. Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. Vet. Parasitol. 149(1-2), 65-71 (2007).