UM-424

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MedKoo CAT#: 585335

CAS#: 58520-98-2

Description: UM-424 is a quarternary ammonium compound that has antiarrhythmic and hemodynamic effects.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-31. Prices are subject to change without notice.

UM-424 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585335
Name: UM-424
CAS#: 58520-98-2
Chemical Formula: C20H28ClNO2
Exact Mass: 349.1809
Molecular Weight: 349.899
Elemental Analysis: C, 68.65; H, 8.07; Cl, 10.13; N, 4.00; O, 9.14


Synonym: UM-424; UM424; UM 424

IUPAC/Chemical Name: [2-hydroxy-3-(2-phenylphenoxy)propyl]-dimethyl-propan-2-ylazanium;chloride

InChi Key: JIFGWFKXUFWHTI-UHFFFAOYSA-M

InChi Code: InChI=1S/C20H28NO2.ClH/c1-16(2)21(3,4)14-18(22)15-23-20-13-9-8-12-19(20)17-10-6-5-7-11-17;/h5-13,16,18,22H,14-15H2,1-4H3;1H/q+1;/p-1

SMILES Code: CC([N+](C)(CC(O)COC1=CC=CC=C1C2=CC=CC=C2)C)C.[Cl-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kniffen FJ, Winokur S, Counsell RE, Lucchesi BR. The antiarrhythmic and cardiovascular properties of 1-dimethyl isopropylamino-3-(2-phenylphenoxy)-propan-2-ol chloride, UM-424. J Pharmacol Exp Ther. 1976 Feb;196(2):420-32. PubMed PMID: 3643.

2: Lynch JJ, Montgomery DG, Nelson SD, Huante DM, Lucchesi BR. Lack of concordance between the antiarrhythmic and antifibrillatory actions of UM-424, a quaternary ammonium analogue of propranolol. J Cardiovasc Pharmacol. 1987 Apr;9(4):414-24. PubMed PMID: 2438504.

3: Gibson JK, Patterson E, Lucchesi BR. The antiarrhythmic actions of intravenous and oral UM424 in postinfarction canine myocardium. J Cardiovasc Pharmacol. 1985 Mar-Apr;7(2):211-8. PubMed PMID: 2581070.