UH 301

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MedKoo CAT#: 585325

CAS#: 127126-21-0

Description: UH 301 is a 5-HT1A receptor antagonist.


Price and Availability

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Pricing updated 2020-10-30. Prices are subject to change without notice.

UH 301 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585325
Name: UH 301
CAS#: 127126-21-0
Chemical Formula: C16H24FNO
Exact Mass: 265.1842
Molecular Weight: 265.3724
Elemental Analysis: C, 72.42; H, 9.12; F, 7.16; N, 5.28; O, 6.03


Synonym: UH 301; UH301; UH-301

IUPAC/Chemical Name: 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, (S)-

InChi Key: FNKBVTBXFLSTPB-LBPRGKRZSA-N

InChi Code: InChI=1S/C16H24FNO/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17/h7-8,12,19H,3-6,9-11H2,1-2H3/t12-/m0/s1

SMILES Code: OC1=C2C[C@@H](N(CCC)CCC)CCC2=C(F)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Yan H, Yu H, Lewander T. An integrative pharmacokinetic and pharmacodynamic study of the 5-HT1A receptor antagonist (S)-UH-301 in the rat. Eur Neuropsychopharmacol. 2002 Apr;12(2):101-10. PubMed PMID: 11872325.

2: Nomikos GG, Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum. J Neural Transm (Vienna). 1996;103(5):541-54. PubMed PMID: 8811500.

3: Ahlenius S, Henriksson I, Magnusson O, Salmi P. In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):15-9. PubMed PMID: 10082223.

4: Dahlin M, Björk E. Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. Int J Pharm. 2000 Feb 15;195(1-2):197-205. PubMed PMID: 10675697.

5: Darmani NA, Reeves SL. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacol Biochem Behav. 1996 Sep;55(1):1-10. PubMed PMID: 8870031.

6: Moreau JL, Griebel G, Jenck F, Martin JR, Widmer U, Haefely WE. Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys. Brain Res Bull. 1992 Dec;29(6):901-4. PubMed PMID: 1473022.

7: Johansson CE, Meyerson BJ, Hacksell U. The novel 5-HT1A receptor antagonist (S)-UH-301 antagonizes 8-OH-DPAT-induced effects on male as well as female rat copulatory behaviour. Eur J Pharmacol. 1991 Sep 4;202(1):81-7. PubMed PMID: 1838499.

8: Arborelius L, Nomikos GG, Hertel P, Salmi P, Grillner P, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1996 May;353(6):630-40. PubMed PMID: 8738296.

9: Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 blocks the qR)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. J Neural Transm Gen Sect. 1994;96(3):179-86. PubMed PMID: 7826569.

10: Arborelius L, Chergui K, Murase S, Nomikos GG, Höök BB, Chouvet G, Hacksell U, Svensson TH. The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn Schmiedebergs Arch Pharmacol. 1993 Apr;347(4):353-62. PubMed PMID: 8510763.

11: Nomikos GG, Arborelius L, Svensson TH. The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. Eur J Pharmacol. 1992 Jun 17;216(3):373-8. PubMed PMID: 1425929.

12: Björk L, Fredriksson A, Hacksell U, Lewander T. Effects of (R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of (R)-8-OH-DPAT-induced effects. Eur Neuropsychopharmacol. 1992 Jun;2(2):141-7. PubMed PMID: 1385999.

13: Stevens KE, O'Neill HC, Rose GM, Luthman J. The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids. 2006 Nov;31(4):365-75. Epub 2006 Aug 2. PubMed PMID: 16868646.

14: Koprowska M, Krotewicz M, Romaniuk A, Strzelczuk M, Wieczorek M. Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats. Acta Neurobiol Exp (Wars). 2002;62(2):63-74. Erratum in: Acta Neurobiol Exp (Warsz). 2002;62(4):283.. PubMed PMID: 12201034.

15: Björk L, Lindgren S, Hacksell U, Lewander T. (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat. Eur J Pharmacol. 1991 Jul 9;199(3):367-70. PubMed PMID: 1833212.

16: Sylte I, Edvardsen O, Dahl SG. Molecular modelling of UH-301 and 5-HT(1a) receptor interactions. Protein Eng. 1996 Feb;9(2):149-60. PubMed PMID: 9005436.

17: Arborelius L, Nomikos GG, Grillner P, Hertel P, Höök BB, Hacksell U, Svensson TH. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):157-65. PubMed PMID: 7477438.

18: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. PubMed PMID: 19837141.

19: Meneses A, Hong E. 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats. Neurobiol Learn Mem. 1999 Mar;71(2):207-18. PubMed PMID: 10082640.

20: Griebel G, Rodgers RJ, Perrault G, Sanger DJ. Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists. Psychopharmacology (Berl). 1999 May;144(2):121-30. PubMed PMID: 10394992.