UH 232

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MedKoo CAT#: 585324

CAS#: 95999-11-4

Description: UH 232 is a dopamine receptor antagonist.


Price and Availability

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Pricing updated 2020-10-29. Prices are subject to change without notice.

UH 232 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585324
Name: UH 232
CAS#: 95999-11-4
Chemical Formula: C18H29NO
Exact Mass: 275.2249
Molecular Weight: 275.436
Elemental Analysis: C, 78.49; H, 10.61; N, 5.09; O, 5.81


Synonym: UH 232; UH232; UH-232

IUPAC/Chemical Name: (1R,2S)-5-methoxy-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine

InChi Key: BTOJYCTUJJHANF-PBHICJAKSA-N

InChi Code: InChI=1S/C18H29NO/c1-5-12-19(13-6-2)17-11-10-16-15(14(17)3)8-7-9-18(16)20-4/h7-9,14,17H,5-6,10-13H2,1-4H3/t14-,17+/m1/s1

SMILES Code: CCCN(CCC)[C@@H]1[C@H](C)C2=C(C(OC)=CC=C2)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Svensson K, Hjorth S, Clark D, Carlsson A, Wikström H, Andersson B, Sanchez D, Johansson AM, Arvidsson LE, Hacksell U, et al. (+)-UH 232 and (+)-UH 242: novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors. J Neural Transm. 1986;65(1):1-27. PubMed PMID: 3083041.

2: Svensson K, Johansson AM, Magnusson T, Carlsson A. (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334(3):234-45. PubMed PMID: 2880302.

3: Piercey MF, Lum JT. Electrophysiological effects of dopamine autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232. Eur J Pharmacol. 1990 Jul 3;182(2):219-26. PubMed PMID: 2397740.

4: Svensson K, Carlsson M, Carlsson A, Hjorth S, Johansson AM, Eriksson E. The putatively selective dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 stimulate prolactin release in rats. Eur J Pharmacol. 1986 Nov 4;130(3):237-42. PubMed PMID: 3792447.

5: Braszko JJ. (+)-UH 232, a partial agonist of the D3 dopamine receptors, attenuates cognitive effects of angiotensin IV and des-Phe(6)-angiotensin IV in rats. Eur Neuropsychopharmacol. 2010 Apr;20(4):218-25. doi: 10.1016/j.euroneuro.2009.11.012. Epub 2009 Dec 30. PubMed PMID: 20042318.

6: Callahan PM, Piercey MF, Cunningham KA. Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine. Psychopharmacology (Berl). 1992;107(1):73-7. PubMed PMID: 1589564.

7: Cooper SJ, Rusk IN, Barber DJ. Yawning induced by the selective dopamine D2 agonist N-0437 is blocked by the selective dopamine autoreceptor antagonist (+)-UH 232. Physiol Behav. 1989 Jun;45(6):1263-6. PubMed PMID: 2573095.

8: Hajos M, Hjorth S, Svensson K, Carlsson A. In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion. Exp Brain Res. 1988;70(3):577-84. PubMed PMID: 3133239.

9: Svensson A, Carlsson M, Carlsson A. Synergistic interactions between the NMDA antagonist dizocilpine and the preferential dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 with regard to locomotor stimulation in monoamine-depleted mice. J Neural Transm Gen Sect. 1991;85(1):69-77. PubMed PMID: 1867840.

10: Gifford AN, Johnson KM. A pharmacological analysis of the effects of (+)-AJ 76 and (+)-UH 232 at release regulating pre- and postsynaptic dopamine receptors. Eur J Pharmacol. 1993 Jun 24;237(2-3):169-75. PubMed PMID: 8103459.

11: Smith A, Piercey M, Roberts DC. Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats. Psychopharmacology (Berl). 1995 Jul;120(1):93-8. PubMed PMID: 7480540.

12: Audinot V, Newman-Tancredi A, Gobert A, Rivet JM, Brocco M, Lejeune F, Gluck L, Desposte I, Bervoets K, Dekeyne A, Millan MJ. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97. PubMed PMID: 9765337.

13: Lin H, Saisch SG, Strange PG. Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor. Br J Pharmacol. 2006 Oct;149(3):291-9. Epub 2006 Aug 21. PubMed PMID: 16921389; PubMed Central PMCID: PMC2014272.

14: Schindler CW, Gilman JP, Bergman J, Mello NK, Woosley RL, Goldberg SR. Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. J Pharmacol Exp Ther. 2002 Jan;300(1):180-7. PubMed PMID: 11752114.

15: Griffon N, Pilon C, Schwartz JC, Sokoloff P. The preferential dopamine D3 receptor ligand, (+)-UH232, is a partial agonist. Eur J Pharmacol. 1995 Aug 25;282(1-3):R3-4. PubMed PMID: 7498261.

16: Waters N, Lagerkvist S, Löfberg L, Piercey M, Carlsson A. The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study. Eur J Pharmacol. 1993 Sep 28;242(2):151-63. PubMed PMID: 8253112.

17: Timmerman W, Rusk IN, Tepper P, Horn AS, Cooper SJ. The effects of the enantiomers of the dopamine agonist N-0437 on food consumption and yawning behaviour in rats. Eur J Pharmacol. 1989 Dec 12;174(1):107-14. PubMed PMID: 2575532.

18: Kleven MS, Koek W. Dopamine D2 receptors play a role in the (-)-apomorphine-like discriminative stimulus effects of (+)-PD 128907. Eur J Pharmacol. 1997 Feb 19;321(1):1-4. PubMed PMID: 9083778.

19: Coldwell MC, Boyfield I, Brown AM, Stemp G, Middlemiss DN. Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1999 Jul;127(5):1135-44. PubMed PMID: 10455259; PubMed Central PMCID: PMC1566129.

20: Caine SB, Geyer MA, Swerdlow NR. Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat. Neuropsychopharmacology. 1995 Apr;12(2):139-45. PubMed PMID: 7779242.