WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 471033
Description: CGP52411, also known as DAPH, is a selective inhibitor of the epidermal growth factor receptor (EGFR). It is also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. It may offer therapeutic agents for the treatment of hyperproliferative diseases.
MedKoo Cat#: 471033
Chemical Formula: C20H15N3O2
Exact Mass: 329.1164
Molecular Weight: 329.36
Elemental Analysis: C, 72.94; H, 4.59; N, 12.76; O, 9.72
Synonym: CGP52411; CGP 52411; CGP-52411; DAPH
IUPAC/Chemical Name: 5,6-bis(phenylamino)isoindoline-1,3-dione
InChi Key: AAALVYBICLMAMA-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
SMILES Code: O=C1NC(C2=CC(NC3=CC=CC=C3)=C(C=C21)NC4=CC=CC=C4)=O
1. Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256
2. Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848
3. Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396