U46,195

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MedKoo CAT#: 585316

CAS#: 141490-47-3

Description: U46,195 stimulates the production of tissue-type plasminogen activator, and is a PAF antagonist.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-23. Prices are subject to change without notice.

U46,195 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585316
Name: U46,195
CAS#: 141490-47-3
Chemical Formula: C17H13ClN4O
Exact Mass: 324.0778
Molecular Weight: 324.768
Elemental Analysis: C, 62.87; H, 4.03; Cl, 10.92; N, 17.25; O, 4.93


Synonym: U46,195; U 46,195; U-46,195; U 46195; U46195; U-46195

IUPAC/Chemical Name: 3-(8-chloro-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl)phenol

InChi Key: GGQZNQSJWZEGBR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13ClN4O/c1-10-20-21-16-9-19-17(11-3-2-4-13(23)7-11)14-8-12(18)5-6-15(14)22(10)16/h2-8,23H,9H2,1H3

SMILES Code: OC1=CC=CC(C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C24)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Torr SR, Haskel EJ, VonVoigtlander PF, Bergmann SR, Abendschein DR. Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor. J Am Coll Cardiol. 1991 Dec;18(7):1804-10. PubMed PMID: 1960333.

2: Kooistra T, Toet K, Kluft C, VonVoigtlander PF, Ennis MD, Aiken JW, Boadt JA, Erickson LA. Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells. Biochem Pharmacol. 1993 Jul 6;46(1):61-7. PubMed PMID: 8347138.