ALW-II-49-7

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MedKoo CAT#: 465020

CAS#: 1135219-23-6

Description: ALW-II-49-7 targets DDR2 and DDR1. Other targets of ALW-II-49-7 are RAF1 and LYN. ALW-II-49-7 shows antiproliferative activity against DDR2-mutated lung cancer cell lines NCI-H2286 and HCC-366.


Chemical Structure

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ALW-II-49-7
CAS# 1135219-23-6

Theoretical Analysis

MedKoo Cat#: 465020
Name: ALW-II-49-7
CAS#: 1135219-23-6
Chemical Formula: C21H17F3N4O2
Exact Mass: 414.1304
Molecular Weight: 414.39
Elemental Analysis: C, 60.87; H, 4.14; F, 13.75; N, 13.52; O, 7.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1135219-23-6;  

Synonym: ALWII497; ALW II 49 7; ALW-II-49-7

IUPAC/Chemical Name: 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3- carboxamide

InChi Key: SAAYRHKJHDIDPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17F3N4O2/c1-12-5-6-13(8-18(12)27-17-7-14(19(25)29)10-26-11-17)20(30)28-16-4-2-3-15(9-16)21(22,23)24/h2-11,27H,1H3,(H2,25,29)(H,28,30)

SMILES Code: CC1=CC=C(C=C1NC1=CN=CC(=C1)C(N)=O)C(=O)NC1=CC=CC(=C1)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 414.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Terai H, Tan L, Beauchamp EM, Hatcher JM, Liu Q, Meyerson M, Gray NS, Hammerman PS. Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. ACS Chem Biol. 2015 Dec 18;10(12):2687-96. doi: 10.1021/acschembio.5b00655. Epub 2015 Sep 25. PubMed PMID: 26390252; PubMed Central PMCID: PMC4685943.

2. https://graylab.dana-farber.org/probes.html

3. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4467-4470