WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555695
CAS#: 2189700-03-4
Description: PSB-17365 is a potent GPR84 agonist. PSB-17365 exhibits EC50 values vs. GPR84 of 2.5nM in a cAMP accumulation assay, and 100nM in a β-arrestin 2 recruitment assay. No direct binding affinities are provided. PSB-17365 is selective for GPR84 compared to other free fatty acid receptors (FFAR1 and FFAR4). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.
MedKoo Cat#: 555695
Name: PSB-17365
CAS#: 2189700-03-4
Chemical Formula: C12H12BrN3O2
Exact Mass: 309.0113
Molecular Weight: 310.151
Elemental Analysis: C, 46.47; H, 3.90; Br, 25.76; N, 13.55; O, 10.32
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Synonym: PSB-17365; PSB 17365; PSB17365;
IUPAC/Chemical Name: 6-((4-bromophenethyl)amino)pyrimidine-2,4(1H,3H)-dione
InChi Key: XGNIAOMGYRRHNY-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12BrN3O2/c13-9-3-1-8(2-4-9)5-6-14-10-7-11(17)16-12(18)15-10/h1-4,7H,5-6H2,(H3,14,15,16,17,18)
SMILES Code: O=C1NC(C=C(NCCC2=CC=C(Br)C=C2)N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 310.151 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von
Kügelgen I, Müller CE. 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid
Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84
(GPR84). ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092.
Epub 2018 Mar 20. PubMed PMID: 30023867; PubMed Central PMCID: PMC6044507.
