WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555694

CAS#: 72255-76-6 (free base)

Description: PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.

Chemical Structure

CAS# 72255-76-6 (free base)

Theoretical Analysis

MedKoo Cat#: 555694
Name: PSB-1584
CAS#: 72255-76-6 (free base)
Chemical Formula: C10H17N3O2
Exact Mass: 211.13
Molecular Weight: 211.265
Elemental Analysis: C, 56.85; H, 8.11; N, 19.89; O, 15.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 72255-76-6 (free base)   PSB-1584 HCl    

Synonym: PSB-1584; PSB 1584; PSB1584;

IUPAC/Chemical Name: 6-Hexylamino-2,4(1H,3H)-pyrimidinedione


InChi Code: InChI=1S/C10H17N3O2/c1-2-3-4-5-6-11-8-7-9(14)13-10(15)12-8/h7H,2-6H2,1H3,(H3,11,12,13,14,15)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 211.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, von
Kügelgen I, Müller CE. An Agonist Radioligand for the Proinflammatory
Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J
Med Chem. 2019 Nov 27. doi: 10.1021/acs.jmedchem.9b01339. [Epub ahead of print]
PubMed PMID: 31721581.

2: Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von
Kügelgen I, Müller CE. 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid
Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84
(GPR84). ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092.
Epub 2018 Mar 20. PubMed PMID: 30023867; PubMed Central PMCID: PMC6044507.