WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555694
CAS#: 72255-76-6 (free base)
Description: PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.
MedKoo Cat#: 555694
CAS#: 72255-76-6 (free base)
Chemical Formula: C10H17N3O2
Exact Mass: 211.1321
Molecular Weight: 211.265
Elemental Analysis: C, 56.85; H, 8.11; N, 19.89; O, 15.15
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Related CAS #: 72255-76-6 (free base) PSB-1584 HCl
Synonym: PSB-1584; PSB 1584; PSB1584;
IUPAC/Chemical Name: 6-Hexylamino-2,4(1H,3H)-pyrimidinedione
InChi Key: SDXQSUJXSHUIBQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H17N3O2/c1-2-3-4-5-6-11-8-7-9(14)13-10(15)12-8/h7H,2-6H2,1H3,(H3,11,12,13,14,15)
SMILES Code: O=C1NC(C=C(NCCCCCC)N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 211.265 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Köse M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, von
Kügelgen I, Müller CE. An Agonist Radioligand for the Proinflammatory
Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J
Med Chem. 2019 Nov 27. doi: 10.1021/acs.jmedchem.9b01339. [Epub ahead of print]
PubMed PMID: 31721581.
2: Pillaiyar T, Köse M, Namasivayam V, Sylvester K, Borges G, Thimm D, von
Kügelgen I, Müller CE. 6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid
Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84
(GPR84). ACS Omega. 2018 Mar 31;3(3):3365-3383. doi: 10.1021/acsomega.7b02092.
Epub 2018 Mar 20. PubMed PMID: 30023867; PubMed Central PMCID: PMC6044507.