WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574119
Description: Tyrosol is a fungicide that increases pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in acute lung injury. It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU). Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.
MedKoo Cat#: 574119
Chemical Formula: C8H10O2
Exact Mass: 138.0681
Molecular Weight: 138.17
Elemental Analysis: C, 69.55; H, 7.30; O, 23.16
Synonym: NSC 59876, p-HPEA, Tyrosol
IUPAC/Chemical Name: 4-hydroxy-benzeneethanol
InChi Key: YCCILVSKPBXVIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2
SMILES Code: OC1=CC=C(CCO)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 138.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Brilhante, R.S., Caetano, É.P., Lima, R.A., et al. Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi. Braz. J. Microbiol. 47(4), 917-924 (2016).
2. Wang, W.C., Xia, Y.M., Yang, B., et al. Protective effects of tyrosol against LPS-induced acute lung injury via inhibiting NF-κB and AP-1 activation and activating the HO-1/Nrf2 pathways. Biol. Pharm. Bull. 40(5), 583-593 (2017).
3. Sato, K., Mihara, Y., Kanai, K., et al. Tyrosol ameliorates lipopolysaccharide-induced ocular inflammation in rats via inhibition of nuclear factor (NF)-κB activation. J. Vet. Med. Sci. 78(9), 1429-1438 (2016).
4. Plotnikov, M.B., Aliev, O.I., Sidekhmenova, A.V., et al. Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats. Microvasc. Res. 119, 91-97 (2018).