ABI-231 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533209

CAS#: 2635953-17-0 (HCl)

Description: ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against panels of melanoma and prostate cancer cell lines, is orally bioavailable, and strongly suppress melanoma tumors in vivo. ABI-231 holds great promise as a new generation of orally available tubulin inhibitor.


Chemical Structure

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ABI-231 HCl
CAS# 2635953-17-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 533209
Name: ABI-231 HCl
CAS#: 2635953-17-0 (HCl)
Chemical Formula: C21H20ClN3O4
Exact Mass: 377.1376
Molecular Weight: 413.86
Elemental Analysis: C, 60.95; H, 4.87; Cl, 8.57; N, 10.15; O, 15.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 2635953-17-0 (HCl)   1332881-26-1 (free base)    

Synonym: ABI-231 HCl; ABI-231 hydrochloride; ABI-231; ABI 231; ABI231; Compound 17ya; Sabizabulin; VERU 111;

IUPAC/Chemical Name: (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone hydrochloride

InChi Key: XJDKAFZMXMMMKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19N3O4.ClH/c1-26-17-8-12(9-18(27-2)20(17)28-3)19(25)16-11-23-21(24-16)14-10-22-15-7-5-4-6-13(14)15;/h4-11,22H,1-3H3,(H,23,24);1H

SMILES Code: O=C(C1=CNC(C2=CNC3=C2C=CC=C3)=N1)C4=CC(OC)=C(OC)C(OC)=C4.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 413.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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