R6G alkyne, 6-isomer
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MedKoo CAT#: 558813

CAS#: N/A

Description: Rhodamine 6G (R6G) is a xanthene dye of rhodamine series. Compared to fluorescein, its emission is shifted to red. It is also much more photostable. The fluorophore has a high quantum yield. This R6G product contains a terminal alkyne moiety for the conjugation with azides in the presence of copper (I) catalyst.


Chemical Structure

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R6G alkyne, 6-isomer
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 558813
Name: R6G alkyne, 6-isomer
CAS#: N/A
Chemical Formula: C30H29N3O4
Exact Mass: 495.22
Molecular Weight: 495.580
Elemental Analysis: C, 72.71; H, 5.90; N, 8.48; O, 12.91

Price and Availability

Size Price Availability Quantity
5mg USD 390 2 weeks
25mg USD 700 2 weeks
50mg USD 1145 2 weeks
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Synonym: R6G alkyne, 6-isomer

IUPAC/Chemical Name: (Z)-2-(6-(ethylamino)-3-(ethyliminio)-2,7-dimethyl-3H-xanthen-9-yl)-4-(prop-2-yn-1-ylcarbamoyl)benzoate

InChi Key: QQIQIYOOKKWTRU-MKCFTUBBSA-N

InChi Code: InChI=1S/C30H29N3O4/c1-6-11-33-29(34)19-9-10-20(30(35)36)21(14-19)28-22-12-17(4)24(31-7-2)15-26(22)37-27-16-25(32-8-3)18(5)13-23(27)28/h1,9-10,12-16,31H,7-8,11H2,2-5H3,(H,33,34)(H,35,36)/b32-25-

SMILES Code: CCNC1=C(C)C=C(C(C2=CC(C(NCC#C)=O)=CC=C2C([O-])=O)=C3C=C/4C)C(OC3=CC4=[NH+]\CC)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: R6G alkyne, 6-isomer is a dye. It is part of the rhodamine 6G series, a highly fluorescent rhodamine family dye.
In vitro activity: This study investigated the ground and excited states of 4'-N,N-diethylaminoflavonol (DEA3HF) in an octa acid-based confined medium and in ethanolic solution, both in the presence of Rhodamine 6G. The Stern-Volmer plots suggest a static quenching mechanism for both systems. Reference: Molecules. 2023 May 23;28(11):4260. https://pubmed.ncbi.nlm.nih.gov/37298739/
In vivo activity: This study found that R6G-conjugated AuNP is an effective theranostic agent that prevents the progression of cancer and MDR bacteria, along with contrasting abilities in medical imaging with minimal toxicity observed in in vitro and in vivo assays using zebrafish embryos. Reference: Appl Biochem Biotechnol. 2023 Mar 28. https://pubmed.ncbi.nlm.nih.gov/36976503/

Preparing Stock Solutions

The following data is based on the product molecular weight 495.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Santos FDS, Ramasamy E, da Luz LC, Ramamurthy V, Rodembusch FS. Spectroscopic Insights of an Emissive Complex between 4'-N,N-Diethylaminoflavonol in Octa-Acid Deep-Cavity Cavitand and Rhodamine 6G. Molecules. 2023 May 23;28(11):4260. doi: 10.3390/molecules28114260. PMID: 37298739; PMCID: PMC10254886. 2. Ávila-Sánchez MA, Isaac-Olivé K, Aranda-Lara L, Morales-Ávila E, Plata-Becerril A, Jiménez-Mancilla NP, Ocampo-García B, Estrada JA, Santos-Cuevas CL, Torres-García E, Camacho-López MA. Targeted photodynamic therapy using reconstituted high-density lipoproteins as rhodamine transporters. Photodiagnosis Photodyn Ther. 2022 Mar;37:102630. doi: 10.1016/j.pdpdt.2021.102630. Epub 2021 Nov 17. PMID: 34798347. 3. Pallavi P, Harini K, Crowder S, Ghosh D, Gowtham P, Girigoswami K, Girigoswami A. Rhodamine-Conjugated Anti-Stokes Gold Nanoparticles with Higher ROS Quantum Yield as Theranostic Probe to Arrest Cancer and MDR Bacteria. Appl Biochem Biotechnol. 2023 Mar 28. doi: 10.1007/s12010-023-04475-0. Epub ahead of print. PMID: 36976503. 4. Yang Y, Liu L, Wu X, Wang X, Lu Q, Zhang Z. CO2 fractional laser-assisted transdermal delivery of silk nanofiber carriers in a rabbit ear hypertrophic scar model. Burns Trauma. 2022 Nov 11;10:tkac040. doi: 10.1093/burnst/tkac040. PMID: 36380852; PMCID: PMC9650785.
In vitro protocol: 1. Santos FDS, Ramasamy E, da Luz LC, Ramamurthy V, Rodembusch FS. Spectroscopic Insights of an Emissive Complex between 4'-N,N-Diethylaminoflavonol in Octa-Acid Deep-Cavity Cavitand and Rhodamine 6G. Molecules. 2023 May 23;28(11):4260. doi: 10.3390/molecules28114260. PMID: 37298739; PMCID: PMC10254886. 2. Ávila-Sánchez MA, Isaac-Olivé K, Aranda-Lara L, Morales-Ávila E, Plata-Becerril A, Jiménez-Mancilla NP, Ocampo-García B, Estrada JA, Santos-Cuevas CL, Torres-García E, Camacho-López MA. Targeted photodynamic therapy using reconstituted high-density lipoproteins as rhodamine transporters. Photodiagnosis Photodyn Ther. 2022 Mar;37:102630. doi: 10.1016/j.pdpdt.2021.102630. Epub 2021 Nov 17. PMID: 34798347.
In vivo protocol: 1. Pallavi P, Harini K, Crowder S, Ghosh D, Gowtham P, Girigoswami K, Girigoswami A. Rhodamine-Conjugated Anti-Stokes Gold Nanoparticles with Higher ROS Quantum Yield as Theranostic Probe to Arrest Cancer and MDR Bacteria. Appl Biochem Biotechnol. 2023 Mar 28. doi: 10.1007/s12010-023-04475-0. Epub ahead of print. PMID: 36976503. 2. Yang Y, Liu L, Wu X, Wang X, Lu Q, Zhang Z. CO2 fractional laser-assisted transdermal delivery of silk nanofiber carriers in a rabbit ear hypertrophic scar model. Burns Trauma. 2022 Nov 11;10:tkac040. doi: 10.1093/burnst/tkac040. PMID: 36380852; PMCID: PMC9650785.

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Gao, F.; Hunter, A.; Qu, S.; Hoffman, J.R.; Gao, P.; Phillip, W.A. Interfacial Junctions Control Electrolyte Transport Through Charge-Patterned Membranes. ACS Nano, 2019, 13(7), 7655–7664. doi: 10.1021/acsnano.9b00780