673-A
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MedKoo CAT#: 574075

CAS#: 109437-62-9

Description: 673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). 673-A also overcomes chemotherapy resistance in vivo.


Chemical Structure

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673-A
CAS# 109437-62-9

Theoretical Analysis

MedKoo Cat#: 574075
Name: 673-A
CAS#: 109437-62-9
Chemical Formula: C15H13NO
Exact Mass: 223.0997
Molecular Weight: 223.27
Elemental Analysis: C, 80.69; H, 5.87; N, 6.27; O, 7.17

Price and Availability

Size Price Availability Quantity
10.0mg USD 340.0 2 Weeks
50.0mg USD 1120.0 2 Weeks
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Synonym: 673 A, 673A, 673-A

IUPAC/Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde

InChi Key: GSAVXYHVHQTGEA-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13NO/c17-11-12-5-7-15(8-6-12)16-9-13-3-1-2-4-14(13)10-16/h1-8,11H,9-10H2

SMILES Code: O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 223.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894

673-A

10.0mg / USD 340.0