WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574063
Description: 4-Thiouridine, also known as 4-SU, is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.
MedKoo Cat#: 574063
Chemical Formula: C9H12N2O5S
Exact Mass: 260.0467
Molecular Weight: 260.26
Elemental Analysis: C, 41.53; H, 4.65; N, 10.76; O, 30.74; S, 12.32
Synonym: 4-Thiouridine, 4-SU
IUPAC/Chemical Name: 4-thio-uridine
InChi Key: ZLOIGESWDJYCTF-XVFCMESISA-N
InChi Code: InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
SMILES Code: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=S)O1
Appearance: Yellow Solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: DMSO (Slightly), Methanol (Slightly)
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 260.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Burger, K., Mühl, B., Kellner, M., et al. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 10(10), 1623-1630 (2013).
2. Thomas, G., and Favre, A. 4-Thiouridine triggers both growth delay induced by near-ultraviolet light and photoprotection. European Journal of Biochemistry 113(1), 67-74 (1980).
3. Harris, M.E., and Christian, E.L. RNA crosslinking methods. Methods in Enzymology 468, 127-146 (2009).