WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533078
CAS#: 2369751-30-2
Description: G150 is a Novel potent and highly selective human cGAS inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 10.2 nM and 25000 nM for h-cGAS and m-cGAS, respectively).
MedKoo Cat#: 533078
Name: G150
CAS#: 2369751-30-2
Chemical Formula: C18H16Cl2N4O2
Exact Mass: 390.065
Molecular Weight: 391.252
Elemental Analysis: C, 55.26; H, 4.12; Cl, 18.12; N, 14.32; O, 8.18
Synonym: G150; G-150; G 150
IUPAC/Chemical Name: 1-(9-(6-Aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
InChi Key: VVUOUIPXYFIWLE-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22)
SMILES Code: O=C(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=CC=C(N)N=C4)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 391.252 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
