A2AR agonist-1
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MedKoo CAT#: 574042

CAS#: 41552-95-8

Description: A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1). A2AR agonist-1 also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.


Chemical Structure

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A2AR agonist-1
CAS# 41552-95-8

Theoretical Analysis

MedKoo Cat#: 574042
Name: A2AR agonist-1
CAS#: 41552-95-8
Chemical Formula: C20H22N6O4
Exact Mass: 410.1703
Molecular Weight: 410.43
Elemental Analysis: C, 58.53; H, 5.40; N, 20.48; O, 15.59

Price and Availability

Size Price Availability Quantity
1.0mg USD 310.0 2 Weeks
5.0mg USD 725.0 2 Weeks
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Synonym: A2AR agonist-1, JMF 1907, JMF1907, JMF-1907

IUPAC/Chemical Name: N-[2-(1H-indol-3-yl)ethyl]-adenosine

InChi Key: QGCNEMXXKWZPHR-WVSUBDOOSA-N

InChi Code: InChI=1S/C20H22N6O4/c27-8-14-16(28)17(29)20(30-14)26-10-25-15-18(23-9-24-19(15)26)21-6-5-11-7-22-13-4-2-1-3-12(11)13/h1-4,7,9-10,14,16-17,20,22,27-29H,5-6,8H2,(H,21,23,24)/t14-,16-,17-,20-/m1/s1

SMILES Code: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NCCC4=CNC5=C4C=CC=C5)N=CN=C32

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 410.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Chen, J.-B., Liu, E.M., Chern, T.-R., et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. Chem. Med. Chem. 6(8), 1390-1400 (2011).

2. Kao, Y.H., Lin, M.S., Chen, C.M., et al. Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease. Hum. Mol. Genet. 26(3), 467-478 (2017).