WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585219
CAS#: 94-07-5
Description: Oxedrine is a sympathetic alpha-adrenergic agonist with actions like Phenylephrine. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
MedKoo Cat#: 585219
Name: Oxedrine
CAS#: 94-07-5
Chemical Formula: C9H13NO2
Exact Mass: 167.0946
Molecular Weight: 167.208
Elemental Analysis: C, 64.65; H, 7.84; N, 8.38; O, 19.14
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Oxedrine; S 38537-9; S38537-9; S-38537-9
IUPAC/Chemical Name: (RS)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol
InChi Key: YRCWQPVGYLYSOX-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3
SMILES Code: CNCC(O)C1=CC=C(O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 167.208 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Stohs SJ. Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine. Phytother Res. 2017 Oct;31(10):1463-1474. doi: 10.1002/ptr.5879. Epub 2017 Jul 28. Review. PubMed PMID: 28752649; PubMed Central PMCID: PMC5655712.
2: Bakhyia N, Dusemund B, Richter K, Lindtner O, Hirsch-Ernst KI, Schäfer B, Lampen A. [Risk assessment of synephrine in dietary supplements]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Mar;60(3):323-331. doi: 10.1007/s00103-016-2506-5. Review. German. PubMed PMID: 28058460.
3: Jung YP, Earnest CP, Koozehchian M, Galvan E, Dalton R, Walker D, Rasmussen C, Murano PS, Greenwood M, Kreider RB. Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance. J Int Soc Sports Nutr. 2017 Jan 12;14:3. doi: 10.1186/s12970-016-0159-2. eCollection 2017. PubMed PMID: 28096758; PubMed Central PMCID: PMC5234109.
4: Gutiérrez-Hellín J, Del Coso J. Dose-Response Effects of p-Synephrine on Fat Oxidation Rate During Exercise of Increasing Intensity. Phytother Res. 2018 Feb;32(2):370-374. doi: 10.1002/ptr.5937. Epub 2017 Oct 11. PubMed PMID: 29024325.
5: Stohs SJ, Badmaev V. A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytother Res. 2016 May;30(5):732-40. doi: 10.1002/ptr.5583. Epub 2016 Feb 9. Review. PubMed PMID: 26856274; PubMed Central PMCID: PMC5067548.
6: Suntar I, Khan H, Patel S, Celano R, Rastrelli L. An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Oxid Med Cell Longev. 2018 May 2;2018:7864269. doi: 10.1155/2018/7864269. eCollection 2018. Review. PubMed PMID: 29854097; PubMed Central PMCID: PMC5954905.
7: Ratamess NA, Bush JA, Stohs SJ, Ellis NL, Vought IT, O'Grady EA, Kuper JD, Hasan SB, Kang J, Faigenbaum AD. Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study. Phytother Res. 2018 Jan;32(1):94-102. doi: 10.1002/ptr.5953. Epub 2017 Oct 19. PubMed PMID: 29047215.
8: Gutiérrez-Hellín J, Salinero JJ, Abían-Vicen J, Areces F, Lara B, Gallo C, Puente C, Del Coso J. Acute consumption of p-synephrine does not enhance performance in sprint athletes. Appl Physiol Nutr Metab. 2016 Jan;41(1):63-9. doi: 10.1139/apnm-2015-0299. Epub 2015 Oct 6. PubMed PMID: 26673246.
9: Zhang Y, Wang S, Luo J, Lin Y, Xu X, Han C, Kong L. Preparative enantioseparation of synephrine by conventional and pH-zone-refining counter-current chromatography. J Chromatogr A. 2018 Nov 9;1575:122-127. doi: 10.1016/j.chroma.2018.09.012. Epub 2018 Sep 7. PubMed PMID: 30224280.
10: Shara M, Stohs SJ, Smadi MM. Safety evaluation of p-synephrine following 15 days of oral administration to healthy subjects: A clinical study. Phytother Res. 2018 Jan;32(1):125-131. doi: 10.1002/ptr.5956. Epub 2017 Nov 12. PubMed PMID: 29130542.
11: Gutiérrez-Hellín J, Del Coso J. Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise. Med Sci Sports Exerc. 2018 Sep;50(9):1899-1906. doi: 10.1249/MSS.0000000000001653. PubMed PMID: 29727404.
12: Shara M, Stohs SJ, Mukattash TL. Cardiovascular Safety of Oral p-Synephrine (Bitter Orange) in Healthy Subjects: A Randomized Placebo-Controlled Cross-over Clinical Trial. Phytother Res. 2016 May;30(5):842-7. doi: 10.1002/ptr.5590. Epub 2016 Mar 7. PubMed PMID: 26948284.
13: Cui Z, Lee Y, Lee Y, Park D. p-Synephrine suppresses glucose production but not lipid accumulation in H4IIE liver cells. J Med Food. 2015 Jan;18(1):76-82. doi: 10.1089/jmf.2013.3133. PubMed PMID: 25379695; PubMed Central PMCID: PMC4281838.
14: Jung YP, Earnest CP, Koozehchian M, Cho M, Barringer N, Walker D, Rasmussen C, Greenwood M, Murano PS, Kreider RB. Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. J Int Soc Sports Nutr. 2017 Jan 3;14:1. doi: 10.1186/s12970-016-0158-3. eCollection 2017. PubMed PMID: 28096757; PubMed Central PMCID: PMC5234097.
15: Maldonado MR, Bracht L, de Sá-Nakanishi AB, Corrêa RCG, Comar JF, Peralta RM, Bracht A. Actions of p-synephrine on hepatic enzyme activities linked to carbohydrate metabolism and ATP levels in vivo and in the perfused rat liver. Cell Biochem Funct. 2018 Jan;36(1):4-12. doi: 10.1002/cbf.3311. Epub 2017 Dec 21. PubMed PMID: 29270996.
16: Roh KB, Kim IH, Kim YS, Lee M, Lee JA, Jung E, Park D. Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway. Molecules. 2014 Aug 8;19(8):11883-95. doi: 10.3390/molecules190811883. PubMed PMID: 25111027; PubMed Central PMCID: PMC6271232.
17: Tette PA, Guidi LR, Bastos EM, Fernandes C, Gloria MB. Synephrine - A potential biomarker for orange honey authenticity. Food Chem. 2017 Aug 15;229:527-533. doi: 10.1016/j.foodchem.2017.02.108. Epub 2017 Feb 23. PubMed PMID: 28372211.
18: Ratamess NA, Bush JA, Kang J, Kraemer WJ, Stohs SJ, Nocera VG, Leise MD, Diamond KB, Faigenbaum AD. The effects of supplementation with P-Synephrine alone and in combination with caffeine on resistance exercise performance. J Int Soc Sports Nutr. 2015 Sep 17;12:35. doi: 10.1186/s12970-015-0096-5. eCollection 2015. PubMed PMID: 26388707; PubMed Central PMCID: PMC4573476.
19: Rossato LG, Costa VM, Limberger RP, Bastos Mde L, Remião F. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011 Jan;49(1):8-16. doi: 10.1016/j.fct.2010.11.007. Epub 2010 Nov 12. Review. PubMed PMID: 21075161.
20: Tanaka S, Sekiguchi M, Yamamoto A, Aizawa SI, Sato K, Taga A, Terashima H, Ishihara Y, Kodama S. Separation of Synephrine Enantiomers in Citrus Fruits by a Reversed Phase HPLC after Chiral Precolumn Derivatization. Anal Sci. 2019 Apr 10;35(4):407-412. doi: 10.2116/analsci.18P441. Epub 2018 Dec 14. PubMed PMID: 30555107.
