SGC2085 free base
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MedKoo CAT#: 408044

CAS#: 1821908-48-8 (free base)

Description: SGC2085 is a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.


Chemical Structure

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SGC2085 free base
CAS# 1821908-48-8 (free base)

Theoretical Analysis

MedKoo Cat#: 408044
Name: SGC2085 free base
CAS#: 1821908-48-8 (free base)
Chemical Formula: C19H24N2O2
Exact Mass: 312.18
Molecular Weight: 312.410
Elemental Analysis: C, 73.05; H, 7.74; N, 8.97; O, 10.24

Price and Availability

Size Price Availability Quantity
50mg USD 450 2-3 weeks
100mg USD 750 2-3 weeks
200mg USD 1250 2-3 weeks
500mg USD 2650 2-3 weeks
1g USD 3950 2-3 weeks
2g USD 6650 2-3 weeks
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Related CAS #: 1821908-49-9 (HCl)   1821908-48-8 (free base)    

Synonym: SGC2085 free base; SGC2085; SGC-2085; SGC 2085;

IUPAC/Chemical Name: (S)-2-amino-N-(4-(3,5-dimethylphenoxy)-3-methylbenzyl)propanamide

InChi Key: GLFOFXKMALJTCZ-HNNXBMFYSA-N

InChi Code: InChI=1S/C19H24N2O2/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20/h5-10,15H,11,20H2,1-4H3,(H,21,22)/t15-/m0/s1

SMILES Code: C[C@H](N)C(NCC1=CC=C(OC2=CC(C)=CC(C)=C2)C(C)=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: SGC2085 is a potent and selective inhibitor of CARM1 with an IC50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins.
In vitro activity: Two structure-based rounds of optimization produced SGC2085, a CARM1 inhibitor with an IC50 of 50 nM and more than hundred-fold selectivity over other PRMTs. Reference: J Med Chem. 2016 Jul 28;59(14):6838-47. https://pubmed.ncbi.nlm.nih.gov/27390919/
In vivo activity: To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47. doi: 10.1021/acs.jmedchem.6b00668. Epub 2016 Jul 8. Erratum in: J Med Chem. 2016 Aug 25;59(16):7698. PMID: 27390919.
In vitro protocol: 1. Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47. doi: 10.1021/acs.jmedchem.6b00668. Epub 2016 Jul 8. Erratum in: J Med Chem. 2016 Aug 25;59(16):7698. PMID: 27390919.
In vivo protocol: To be determined

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1: Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ,
Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. Discovery
of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1
(CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47.
doi: 10.1021/acs.jmedchem.6b00668. Epub 2016 Jul 8. Erratum in: J Med Chem. 2016
Aug 25;59(16):7698. PubMed PMID: 27390919.