WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585202

CAS#: 5027-63-4

Description: Saccharolactone is used as index for assessing induction of hepatic enzymes by anticonvulsants.

Chemical Structure

CAS# 5027-63-4

Theoretical Analysis

MedKoo Cat#: 585202
Name: Saccharolactone
CAS#: 5027-63-4
Chemical Formula: C7H8O5
Exact Mass: 172.0372
Molecular Weight: 172.136
Elemental Analysis: C, 48.84; H, 4.68; O, 46.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Saccharolactone

IUPAC/Chemical Name: 1,4-Glucarolactone


InChi Code: InChI=1S/C7H8O5/c8-2-5-6-3(9)1-4(11-5)7(10)12-6/h1,3,5-6,8-9H,2H2/t3-,5-,6+/m1/s1

SMILES Code: O[C@@H]1C=C2O[C@H](CO)[C@H]1OC2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 172.136 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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9: Yang W, Zhou G, Zou S, Yang W, Liu A, Sun S, Xie B. Metabonomics of d-glucaro-1,4-lactone in preventing diethylnitrosamine-induced liver cancer in rats. Pharm Biol. 2018 Dec;56(1):643-648. doi: 10.1080/13880209.2018.1525414. PubMed PMID: 31070541; PubMed Central PMCID: PMC6292356.

10: Xie B, Liu Y, Zou H, Son Y, Wang H, Wang H, Shao J. Determination of D-glucaric acid and/or D-glucaro-1,4-lacton in different apple varieties through hydrophilic interaction chromatography. Food Chem. 2016 Jul 15;203:1-7. doi: 10.1016/j.foodchem.2016.02.009. Epub 2016 Feb 2. PubMed PMID: 26948581.

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12: Zółtaszek R, Hanausek M, Kiliańska ZM, Walaszek Z. [The biological role of D-glucaric acid and its derivatives: potential use in medicine]. Postepy Hig Med Dosw (Online). 2008 Sep 5;62:451-62. Review. Polish. PubMed PMID: 18772850.

13: Saluk-Juszczak J, Olas B, Nowak P, Staroń A, Wachowicz B. Protective effects of D-glucaro-1,4-lactone against oxidative modifications in blood platelets. Nutr Metab Cardiovasc Dis. 2008 Jul;18(6):422-8. Epub 2007 Oct 22. PubMed PMID: 17933501.

14: Coddington KA, Swanson SP, Hassan AS, Buck WB. Enterohepatic circulation of T-2 toxin metabolites in the rat. Drug Metab Dispos. 1989 Nov-Dec;17(6):600-5. PubMed PMID: 2575494.

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16: Peyrol J, Meyer G, Obert P, Dangles O, Pechère L, Amiot MJ, Riva C. Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions. J Nutr Biochem. 2018 Jan;51:8-15. doi: 10.1016/j.jnutbio.2017.09.009. Epub 2017 Oct 3. PubMed PMID: 29078076.

17: Xie B, Zhang Z, Gong T, Zhang N, Wang H, Zou H. Application of metabonomic strategy to discover an unreported active ingredient in LiuWeiDiHuang pills suppressing beta-glucuronidase. Anal Bioanal Chem. 2015 Jan;407(2):609-14. doi: 10.1007/s00216-014-8253-2. Epub 2014 Nov 9. PubMed PMID: 25381611.

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20: Kowalczyk MC, Spears E, Narog M, Zoltaszek R, Kowalczyk P, Hanausek M, Yoshimi N, Slaga TJ, Walaszek Z. Modulation of biomarkers related to tumor initiation and promotion in mouse skin by a natural β-glucuronidase inhibitor and its precursors. Oncol Rep. 2011 Sep;26(3):551-6. doi: 10.3892/or.2011.1351. Epub 2011 Jun 17. PubMed PMID: 21687956.