GW284543
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555674

CAS#: 790186-68-4

Description: GW284543, also known as UNC10225170;, is a potent and selective MEK5 inhibitor with the potential for cancer treatment.


Chemical Structure

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GW284543
CAS# 790186-68-4

Theoretical Analysis

MedKoo Cat#: 555674
Name: GW284543
CAS#: 790186-68-4
Chemical Formula: C23H20N2O3
Exact Mass: 372.15
Molecular Weight: 372.424
Elemental Analysis: C, 74.18; H, 5.41; N, 7.52; O, 12.89

Price and Availability

Size Price Availability Quantity
100mg USD 450
200mg USD 750
500mg USD 1450
1g USD 2450
2g USD 4250
Bulk inquiry

Synonym: GW284543; GW-284543; GW 284543; UNC10225170; UNC-10225170; UNC 10225170;

IUPAC/Chemical Name: 6,7-dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine

InChi Key: LEEMRFWMAIVHQY-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20N2O3/c1-26-22-14-19-20(11-12-24-21(19)15-23(22)27-2)25-16-7-6-10-18(13-16)28-17-8-4-3-5-9-17/h3-15H,1-2H3,(H,24,25)

SMILES Code: COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: GW284543 (UNC10225170) is a selective MEK5 inhibitor.
In vitro activity: UNC10225170 treatment dose-dependently inhibited MEK5, as determined by reductions in pERK5, and decreased endogenous MYC protein (Figure 6C). Reference: Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi https://pubmed.ncbi.nlm.nih.gov/30423298/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.0 179.90

Preparing Stock Solutions

The following data is based on the product molecular weight 372.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001. PMID: 30423298; PMCID: PMC6321749.
In vitro protocol: 1. Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001. PMID: 30423298; PMCID: PMC6321749.
In vivo protocol: TBD

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