WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574019

CAS#: 2131223-64-6

Description: YW1128 is an inhibitor of Wnt/β-catenin signaling that decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation.

Chemical Structure

CAS# 2131223-64-6

Theoretical Analysis

MedKoo Cat#: 574019
Name: YW1128
CAS#: 2131223-64-6
Chemical Formula: C20H17N5O
Exact Mass: 343.1433
Molecular Weight: 343.39
Elemental Analysis: C, 69.96; H, 4.99; N, 20.40; O, 4.66

Price and Availability

Size Price Availability Quantity
1.0mg USD 230.0 2 Weeks
5.0mg USD 525.0 2 Weeks
10.0mg USD 895.0 2 Weeks
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Synonym: YW1128

IUPAC/Chemical Name: 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1,2,3-triazole-4-carboxamide


InChi Code: InChI=1S/C20H17N5O/c1-13-7-3-6-10-17(13)25-14(2)19(23-24-25)20(26)22-18-12-11-15-8-4-5-9-16(15)21-18/h3-12H,1-2H3,(H,21,22,26)

SMILES Code: O=C(C1=C(C)N(C2=C(C)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 343.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).


1.0mg / USD 230.0

Additional Information

λmax: 257, 318, 332 nm