WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 408358
CAS#: 791835-21-7
Description: BI-6C9 is an inhibitor of tBid (Kd = 20 µM).
MedKoo Cat#: 408358
Name: BI-6C9
CAS#: 791835-21-7
Chemical Formula: C23H25N3O4S2
Exact Mass: 471.1286
Molecular Weight: 471.59
Elemental Analysis: C, 58.58; H, 5.34; N, 8.91; O, 13.57; S, 13.60
Synonym: BI-6C9; BI 6C9; BI6C9;
IUPAC/Chemical Name: N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide
InChi Key: LCFUJBSKPDPGKO-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)
SMILES Code: O=C(NC1=CC=C(SC2=CC=C(N)C=C2)C=C1)CCCNS(=O)(C3=CC=C(OC)C=C3)=O
1: Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C. Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. Free Radic Biol Med. 2018 Mar;117:45-57. doi: 10.1016/j.freeradbiomed.2018.01.019. Epub 2018 Jan 31. PubMed PMID: 29378335.
2: Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C. BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 2017 Aug;12:558-570. doi: 10.1016/j.redox.2017.03.007. Epub 2017 Mar 9. PubMed PMID: 28384611; PubMed Central PMCID: PMC5382034.
3: Cooley-Andrade O, Cheung K, Chew AN, Connor DE, Parsi K. Detergent sclerosants at sub-lytic concentrations induce endothelial cell apoptosis through a caspase dependent pathway. Apoptosis. 2016 Jul;21(7):836-45. doi: 10.1007/s10495-016-1252-3. PubMed PMID: 27225250.
4: Cooley-Andrade O, Goh WX, Connor DE, Ma DD, Parsi K. Detergent Sclerosants Stimulate Leukocyte Apoptosis and Oncosis. Eur J Vasc Endovasc Surg. 2016 Jun;51(6):846-56. doi: 10.1016/j.ejvs.2016.03.008. Epub 2016 Apr 8. PubMed PMID: 27067723.
5: Hu L, Su C, Song X, Shi Q, Fu J, Xia X, Xu D, Song E, Song Y. Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells. Neurotoxicology. 2015 Jul;49:149-57. doi: 10.1016/j.neuro.2015.06.005. Epub 2015 Jun 23. PubMed PMID: 26112249.
6: Zhang CZ, Fang EF, Zhang HT, Liu LL, Yun JP. Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Invest New Drugs. 2015 Feb;33(1):1-11. doi: 10.1007/s10637-014-0156-8. Epub 2014 Sep 9. PubMed PMID: 25200916.
7: Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G, Zhan Y, Hu T. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Mol Cancer. 2014 Mar 16;13:59. doi: 10.1186/1476-4598-13-59. PubMed PMID: 24628719; PubMed Central PMCID: PMC4007561.
8: Miyake K, Bekisz J, Zhao T, Clark CR, Zoon KC. Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. Biochim Biophys Acta. 2012 Aug;1823(8):1378-88. doi: 10.1016/j.bbamcr.2012.05.031. Epub 2012 Jun 7. PubMed PMID: 22683989; PubMed Central PMCID: PMC3389262.
9: Grohm J, Plesnila N, Culmsee C. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24(5):831-8. doi: 10.1016/j.bbi.2009.11.015. Epub 2009 Dec 2. PubMed PMID: 19961923.
