WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574000
Description: 7,8-Dihydroneopterin is a pteridine with antioxidant activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits copper ion-induced oxidation of LDL. It also decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL, and it inhibits necrosis induced by oxidized LDL (oxLDL).
MedKoo Cat#: 574000
Chemical Formula: C9H13N5O4
Exact Mass: 255.0968
Molecular Weight: 255.23
Elemental Analysis: C, 42.35; H, 5.13; N, 27.44; O, 25.07
Synonym: 7,8-Dihydroneopterin, D-erythro-7,8-Dihydroneopterin
IUPAC/Chemical Name: 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone
InChi Key: YQIFAMYNGGOTFB-XINAWCOVSA-N
InChi Code: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1
SMILES Code: O=C1C2=C(NCC([C@H](O)[C@H](O)CO)=N2)NC(N)=N1
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 255.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Oettl, K., Greilberger, J., and Reibnegger, G. Dihydroneopterin as a scavenger of nitrogen centered radicals. Pteridines 11(3), 90-93 (2000).
2. Gieseg, S.P., Reibnegger, G., Wachter, H., et al. 7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant. Free Radic. Res. 23(2), 123-136 (1995).
3. Gieseg, S.P., and Cato, S. Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin. Redox Rep. 8(2), 113-115 (2003).
4. Baird, S.K., Reid, L., Hampton, M.B., et al. OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochim Biophys. Acta. 1745(3), 361-369 (2005).
λmax: 217, 235, 275, 346 nm