7,8-Dihydroneopterin
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MedKoo CAT#: 574000

CAS#: 1218-98-0

Description: 7,8-Dihydroneopterin is a pteridine with antioxidant activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits copper ion-induced oxidation of LDL. It also decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL, and it inhibits necrosis induced by oxidized LDL (oxLDL).


Chemical Structure

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7,8-Dihydroneopterin
CAS# 1218-98-0

Theoretical Analysis

MedKoo Cat#: 574000
Name: 7,8-Dihydroneopterin
CAS#: 1218-98-0
Chemical Formula: C9H13N5O4
Exact Mass: 255.0968
Molecular Weight: 255.23
Elemental Analysis: C, 42.35; H, 5.13; N, 27.44; O, 25.07

Price and Availability

Size Price Availability Quantity
25.0mg USD 305.0 2 Weeks
250.0mg USD 1450.0 2 Weeks
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Synonym: 7,8-Dihydroneopterin, D-erythro-7,8-Dihydroneopterin

IUPAC/Chemical Name: 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone

InChi Key: YQIFAMYNGGOTFB-XINAWCOVSA-N

InChi Code: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1

SMILES Code: O=C1C2=C(NCC([C@H](O)[C@H](O)CO)=N2)NC(N)=N1

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 255.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Oettl, K., Greilberger, J., and Reibnegger, G. Dihydroneopterin as a scavenger of nitrogen centered radicals. Pteridines 11(3), 90-93 (2000).

2. Gieseg, S.P., Reibnegger, G., Wachter, H., et al. 7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant. Free Radic. Res. 23(2), 123-136 (1995).

3. Gieseg, S.P., and Cato, S. Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin. Redox Rep. 8(2), 113-115 (2003).

4. Baird, S.K., Reid, L., Hampton, M.B., et al. OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochim Biophys. Acta. 1745(3), 361-369 (2005).



Additional Information

λmax: 217, 235, 275, 346 nm