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MedKoo CAT#: 573991
CAS#: 36396-99-3
Description: N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors over A2 receptors. N6-Cyclohexyladenosine decreases heart rate, increases coronary flow, and induces sleep. N6-Cyclohexyladenosine also decreases locomotor activity in mice.
MedKoo Cat#: 573991
Name: N6-Cyclohexyladenosine
CAS#: 36396-99-3
Chemical Formula: C16H23N5O4
Exact Mass: 349.175
Molecular Weight: 349.39
Elemental Analysis: C, 55.00; H, 6.64; N, 20.04; O, 18.32
Synonym: N6-Cyclohexyladenosine
IUPAC/Chemical Name: N-cyclohexyl-adenosine
InChi Key: SZBULDQSDUXAPJ-XNIJJKJLSA-N
InChi Code: InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1
SMILES Code: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NC4CCCCC4)N=CN=C32
1. Hutchison, A.J., Webb, R.L., Oei, H.H., et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 251(1), 47-55 (1989).
2. Blanco-Centurion, C., Xu, M., Murillo-Rodriguez, E., et al. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci. 26(31), 8092-8100 (2006).
3. Nikodijević, O., Daly, J.W., and Jacobson, K.A. Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS Lett. 261(1), 67-70 (1990).