A 582941
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558770

CAS#: 848591-90-2

Description: A-582941 exhibits high-affinity binding and agonism at alpha-7 nicotinic acetylcholine receptor , with pharmacokinetic properties and excellent distribution to the central nervous system. A-582941 activates signaling pathways known to be involved in cognitive functions (ERK1/2 and CREB phosphorylation).


Chemical Structure

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A 582941
CAS# 848591-90-2

Theoretical Analysis

MedKoo Cat#: 558770
Name: A 582941
CAS#: 848591-90-2
Chemical Formula: C17H20N4
Exact Mass: 280.17
Molecular Weight: 280.378
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98

Price and Availability

Size Price Availability Quantity
10.0mg USD 450.0 2 Weeks
50.0mg USD 1450.0 2 Weeks
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Synonym: A582941,A-582941

IUPAC/Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole

InChi Key: GTMRUYCIJSNXGB-GASCZTMLSA-N

InChi Code: 1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3/t14-,15+

SMILES Code: [H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 280.378 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 324 179 PMID: 17959745

A 582941

10.0mg / USD 450.0