A-484954
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MedKoo CAT#: 573979

CAS#: 142557-61-7

Description: A-484954 is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K). It reduces eEF-2K autophosphorylation in PC3, HeLa, H460, H1299, and MDA-MB-231 cancer cells.


Chemical Structure

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A-484954
CAS# 142557-61-7

Theoretical Analysis

MedKoo Cat#: 573979
Name: A-484954
CAS#: 142557-61-7
Chemical Formula: C13H15N5O3
Exact Mass: 289.1175
Molecular Weight: 289.29
Elemental Analysis: C, 53.97; H, 5.23; N, 24.21; O, 16.59

Price and Availability

Size Price Availability Quantity
5.0mg USD 245.0 2 Weeks
10.0mg USD 400.0 2 Weeks
25.0mg USD 680.0 2 Weeks
50.0mg USD 1000.0 2 Weeks
100.0mg USD 1500.0 2 Weeks
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Synonym: A-484954

IUPAC/Chemical Name: 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide

InChi Key: HWODCHXORCTEGU-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)

SMILES Code: O=C1N(CC)C(C(C=C(C(N)=O)C(N)=N2)=C2N1C3CC3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 289.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Edupuganti, R., Wang, Q., Tavares, C.D., et al. Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. Bioorg. Med. Chem. 22(17), 4910-4916 (2014).