Oxychlororaphine
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MedKoo CAT#: 573978

CAS#: 550-89-0

Description: Oxychlororaphine is a phenazine microbial metabolite that has been found in a variety of bacteria and has anticancer, antibacterial, and antifungal activities. It is cytotoxic to A549, HeLa, and SW480 cancer cells. Oxychlororaphine halts the cell cycle at the G1 phase and induces apoptosis in A549 cells. It is active against Streptomyces bacteria and T. mentagrophytes, E. floccosum, C. albicans, M. audouini, and B. dermatitidis fungi.

Chemical Structure

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Oxychlororaphine
CAS# 550-89-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 573978
Name: Oxychlororaphine
CAS#: 550-89-0
Chemical Formula: C13H9N3O
Exact Mass: 223.07
Molecular Weight: 223.235
Elemental Analysis: C, 69.95; H, 4.06; N, 18.82; O, 7.17

Price and Availability

Size Price Availability Quantity
5mg USD 230
10mg USD 385
25mg USD 675
100mg USD 1000
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Synonym: Oxychlororaphine

IUPAC/Chemical Name: 1-phenazinecarboxamide

InChi Key: KPZYYKDXZKFBQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9N3O/c14-13(17)8-4-3-7-11-12(8)16-10-6-2-1-5-9(10)15-11/h1-7H,(H2,14,17)

SMILES Code: NC(C1=CC=CC2=C1N=C3C(C=CC=C3)=N2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.0 44.80

Preparing Stock Solutions

The following data is based on the product molecular weight 223.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Ali, H.M., El-Shikh, M.S., Salem, M.Z.M., et al. Isolation of bioactive phenazine-1-carboxamide from the soil bacterium Pantoea agglomerans and study of its anticancer potency on different cancer cell lines. J. AOAC Int. 99(5), 1233-1239 (2016).

2. Sierra, G., and Veringa, H.A. Effect of oxy-chlororaphin on the growth in vitro of Streptomyces species and some pathogenic fungi. Nature 182(4630), 265 (1958).