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MedKoo CAT#: 555646
CAS#: 2239272-16-1
Description: AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclinical models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate molecule is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.
MedKoo Cat#: 555646
Name: AWZ1066S
CAS#: 2239272-16-1
Chemical Formula: C19H19F3N6O
Exact Mass: 404.1572
Molecular Weight: 404.3972
Elemental Analysis: C, 56.43; H, 4.74; F, 14.09; N, 20.78; O, 3.96
Related CAS #: 2239272-16-1
Synonym: AWZ1066S; AWZ-1066S; AWZ 1066S; AWZ106S; AWZ-1066; AWZ 1066;
IUPAC/Chemical Name: (S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine
InChi Key: IZFVCNUAPFSNCO-LBPRGKRZSA-N
InChi Code: InChI=1S/C19H19F3N6O/c1-12-11-29-9-8-28(12)18-26-16-14(5-3-7-24-16)17(27-18)25-10-13-4-2-6-23-15(13)19(20,21)22/h2-7,12H,8-11H2,1H3,(H,24,25,26,27)/t12-/m0/s1
SMILES Code: FC(C1=NC=CC=C1CNC2=C(C=CC=N3)C3=NC(N4[C@@H](C)COCC4)=N2)(F)F
1: Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook
DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven
A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts
AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F,
Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM. AWZ1066S, a highly
specific anti-Wolbachia drug candidate for a short-course treatment of
filariasis. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi:
10.1073/pnas.1816585116. Epub 2019 Jan 7. PubMed PMID: 30617067; PubMed Central
PMCID: PMC6347715.