ZK824859
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MedKoo CAT#: 555643

CAS#: 2254001-81-3 (free acid)

Description: ZK824859 is a potent uPA inhibitor as a potential treatment for multiple sclerosis. ZK824859 showed activity to lower clinical scores when dosed in either acute or chronic mouse EAE mode.


Chemical Structure

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ZK824859
CAS# 2254001-81-3 (free acid)

Theoretical Analysis

MedKoo Cat#: 555643
Name: ZK824859
CAS#: 2254001-81-3 (free acid)
Chemical Formula: C23H22F2N2O4
Exact Mass: 428.15
Molecular Weight: 428.436
Elemental Analysis: C, 64.48; H, 5.18; F, 8.87; N, 6.54; O, 14.94

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 weeks
100mg USD 750 2 weeks
200mg USD 1250 2 weeks
500mg USD 1950 2 weeks
1g USD 2950 2 weeks
2g USD 5450 2 weeks
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Related CAS #: 2254001-81-3 (free acid)   2436760-76-6 (HCl)  

Synonym: ZK824859; ZK-824859; ZK 824859; CAS#2254001-81-3

IUPAC/Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid

InChi Key: CVNXUNVHFJANHX-HXUWFJFHSA-N

InChi Code: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1

SMILES Code: CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 428.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan
K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C,
Sukovich D, Whitlow M, Chen D, Buckman BO. Discovery of selective urokinase
plasminogen activator (uPA) inhibitors as a potential treatment for multiple
sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi:
10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. PubMed PMID: 30201291.