S 312

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585131

CAS#: 120004-07-1

Description: S 312 is a calcium antagonist.

Chemical Structure

S 312
CAS# 120004-07-1

Theoretical Analysis

MedKoo Cat#: 585131
Name: S 312
CAS#: 120004-07-1
Chemical Formula: C20H22N2O4S
Exact Mass: 386.13
Molecular Weight: 386.466
Elemental Analysis: C, 62.16; H, 5.74; N, 7.25; O, 16.56; S, 8.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S 312; S312; S-312

IUPAC/Chemical Name: Thieno(2,3-b)pyridine-5-carboxylic acid, 4,7-dihydro-6-methyl-3-(2-methylpropyl)-4-(3-nitrophenyl)-, methyl ester, (+-)-


InChi Code: InChI=1S/C20H22N2O4S/c1-11(2)8-14-10-27-19-18(14)17(16(12(3)21-19)20(23)26-4)13-6-5-7-15(9-13)22(24)25/h5-7,9-11,17,21H,8H2,1-4H3

SMILES Code: O=C(C1=C(C)NC2=C(C(CC(C)C)=CS2)C1C3=CC=CC([N+]([O-])=O)=C3)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 386.466 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mihara S, Fujimoto M. Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells. Jpn J Pharmacol. 1991 Jul;56(3):249-59. PubMed PMID: 1832726.

2: Gunderson J, Masland S, Choi-Kain L. Good psychiatric management: a review. Curr Opin Psychol. 2018 Jun;21:127-131. doi: 10.1016/j.copsyc.2017.12.006. Epub 2018 Jan 5. Review. PubMed PMID: 29547739.

3: Gemba T, Ninomiya M, Matsunaga K, Ueda M. Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6- methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats. J Pharmacol Exp Ther. 1993 Apr;265(1):463-7. PubMed PMID: 8474028.

4: Ninomiya M, Tani T, Nakajima S, Ueda M. Effects of S-312, a new calcium antagonist, on the mechanical and electrophysiological responses of isolated cardiovascular preparations. Jpn J Pharmacol. 1989 Oct;51(2):227-38. PubMed PMID: 2593380.

5: Yagami T, Ueda K, Sakaeda T, Itoh N, Sakaguchi G, Okamura N, Hori Y, Fujimoto M. Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol. 2004 Mar 15;67(6):1153-65. PubMed PMID: 15006551.

6: Shimizu T, Kawabata T, Nakamura M. Protective effect of a novel calcium blocker, S-312-d, on ischemic acute renal failure in rat. J Pharmacol Exp Ther. 1990 Nov;255(2):484-90. PubMed PMID: 2243338.

7: Ueda M, Masui M, Kawakami M, Matsunaga K, Gemba T, Ninomiya M, Nakano A, Torii M, Adachi I, Ito H. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spontaneously hypertensive rats. Arzneimittelforschung. 1993 Dec;43(12):1291-303. PubMed PMID: 8141816.

8: Amano T, Aihua Z, Matsubayashi H, Seki T, Serikawa T, Sasa M, Sakai N. Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats. J Pharmacol Sci. 2004 Jul;95(3):355-62. PubMed PMID: 15272212.

9: Eigyo M, Shiomi T, Inoue Y, Sakaguchi I, Ishibashi C, Murata S, Koyabu K, Matsushita A, Adachi I, Ueda M. Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice. Jpn J Pharmacol. 1994 Jun;65(2):175-7. PubMed PMID: 7967231.

10: Nakajima M, Adachi I, Ueda M. Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the brain and on isolated arteries in the Cynomolgus monkey. Arzneimittelforschung. 1993 Dec;43(12):1276-82. PubMed PMID: 8141814.

11: Nakano H, McCormick DB. Stereospecificity of the metal.ATP complex in flavokinase from rat small intestine. J Biol Chem. 1991 Nov 25;266(33):22125-8. PubMed PMID: 1657990.

12: Ueda M, Matsumura S, Masui M, Matsuura E, Kawakami M, Fujitomo H, Umeda T, Kagawa H, Hirohata S, Shima K, et al. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 3rd communication: antihypertensive effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3-b] pyridine-5-carboxylate in hypertensive rats and dogs. Arzneimittelforschung. 1993 Dec;43(12):1282-90. PubMed PMID: 8141815.

13: Ueda M, Matsumura S, Masui M, Matsuura E, Uno O, Kawakami M, Ninomiya M, Adachi I. Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 1st communication: comparative studies on the cardiovascular effects of methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2,3- b]pyridine-5-carboxylate and its two enantiomers in experimental animals. Arzneimittelforschung. 1993 Dec;43(12):1270-5. PubMed PMID: 8141813.

14: Keuroghlian AS, Gunderson JG, Pagano ME, Markowitz JC, Ansell EB, Shea MT, Morey LC, Sanislow C, Grilo CM, Stout RL, Zanarini MC, McGlashan TH, Skodol AE. Interactions of borderline personality disorder and anxiety disorders over 10 years. J Clin Psychiatry. 2015 Nov;76(11):1529-34. doi: 10.4088/JCP.14m09748. PubMed PMID: 26114336.

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18: Yasui M, Kawasaki K. Vulnerability of CA1 neurons in SHRSP hippocampal slices to ischemia, and its protection by Ca2+ channel blockers. Brain Res. 1994 Apr 11;642(1-2):146-52. PubMed PMID: 8032875.

19: Dessy C, Salomone S, Morel N, Godfraind T. Activity of dihydrothienopyridine S312 enantiomers on L-type Ca2+ channels in isolated rat aorta and cerebral microvessels. Eur J Pharmacol. 1993 Feb 16;231(3):435-42. PubMed PMID: 8449235.

20: Jizomoto H, Kanaoka E, Sugita K, Hirano K. Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract. Pharm Res. 1993 Aug;10(8):1115-22. PubMed PMID: 8415395.