WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585124
Description: SX 284 is an antispasmodic that depresses the twitch response of the ileum from guinea pig to electrical stimulation.
MedKoo Cat#: 585124
Name: SX 284
Chemical Formula: C23H24ClN3O
Exact Mass: 393.1608
Molecular Weight: 393.915
Elemental Analysis: C, 70.13; H, 6.14; Cl, 9.00; N, 10.67; O, 4.06
This product is not in stock, which may be available by custom synthesis.
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Synonym: SX 284; SX284; SX-284
IUPAC/Chemical Name: 1,2-Benzisoxazole-3-acetonitrile, alpha-((2-(2-(1-piperidinyl)ethyl)phenyl)methylene)-, monohydrochloride, (E)-
InChi Key: AULSOKMNOZLLMC-LRZQPWDCSA-N
InChi Code: InChI=1S/C23H23N3O.ClH/c24-17-20(23-21-10-4-5-11-22(21)27-25-23)16-19-9-3-2-8-18(19)12-15-26-13-6-1-7-14-26;/h2-5,8-11,16H,1,6-7,12-15H2;1H/b20-16-;
SMILES Code: N#C/C(C1=NOC2=C1C=CC=C2)=C/C3=CC=CC=C3CCN4CCCCC4.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 393.915 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Takayanagi I, Sone H, Kawashima K, Sohji Y, Kadokawa T. A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284). Jpn J Pharmacol. 1982 Dec;32(6):973-9. PubMed PMID: 7161971.
2: Sone H, Takayanagi I. Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum. J Pharmacobiodyn. 1983 Apr;6(4):272-4. PubMed PMID: 6620115.