Aditoprim

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573942

CAS#: 56066-63-8

Description: Aditoprim is an antibacterial dihydrofolate reductase inhibitor.

Chemical Structure

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Aditoprim
CAS# 56066-63-8
Instruction

Theoretical Analysis

MedKoo Cat#: 573942
Name: Aditoprim
CAS#: 56066-63-8
Chemical Formula: C15H21N5O2
Exact Mass: 303.17
Molecular Weight: 303.370
Elemental Analysis: C, 59.39; H, 6.98; N, 23.09; O, 10.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Aditoprim

IUPAC/Chemical Name: 2,4-Diamino-5-(4-(dimethylamino)-3,5-dimethoxybenzyl)pyrimidine

InChi Key: QBQMXWZTRRWPGK-UHFFFAOYSA-N

InChi Code: 1S/C15H21N5O2/c1-20(2)13-11(21-3)6-9(7-12(13)22-4)5-10-8-18-15(17)19-14(10)16/h6-8H,5H2,1-4H3,(H4,16,17,18,19)

SMILES Code: CN(C)c1c(cc(cc1OC)Cc2cnc(nc2N)N)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 303.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cheng G, Xu Y, Zhu X, Xie S, Wang L, Huang L, Hao H, Liu Z, Pan Y, Chen D, Wang Y, Yuan Z. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017 Feb 1;7:41370. doi: 10.1038/srep41370. PubMed PMID: 28145487; PubMed Central PMCID: PMC5286432.

2: Wang L, Huang L, Pan Y, Wu Q, Xie S, Yuan Z. Simultaneous determination of aditoprim and its three major metabolites in pigs, broilers and carp tissues, and its application in tissue distribution and depletion studies. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Aug;33(8):1299-311. doi: 10.1080/19440049.2016.1200751. Epub 2016 Jul 27. PubMed PMID: 27310088.

3: Wang X, Tan Z, Pan Y, Ihsan A, Liu Q, Huang L, Cheng G, Chen D, Tao Y, Liu Z, Yuan Z. Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. J Appl Toxicol. 2015 Nov;35(11):1415-26. doi: 10.1002/jat.3107. Epub 2015 Feb 7. PubMed PMID: 25663419.