WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555620

CAS#: 2374313-54-7

Description: SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 750 Same day
200mg USD 1250 Same day
500mg USD 1950 Same day
1g USD 2950 Same day
2g USD 4650 2 Weeks
5g USD 7650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-19. Prices are subject to change without notice.

SIS-17, purity > 98%, is in stock. The same day shipping after order received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555620
Name: SIS-17
CAS#: 2374313-54-7
Chemical Formula: C21H38N2OS
Exact Mass: 366.2705
Molecular Weight: 366.608
Elemental Analysis: C, 68.80; H, 10.45; N, 7.64; O, 4.36; S, 8.75

Synonym: SIS-17; SIS 17; SIS17;

IUPAC/Chemical Name: N'-hexadecylthiophene-2-carbohydrazide


InChi Code: InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Mammalian histone deacetylases (HDACs) are a class of enzymes that play important roles in biological pathways. Existing HDAC inhibitors target multiple HDACs without much selectivity. Inhibitors that target one particular HDAC will be useful for investigating the biological functions of HDACs and for developing better therapeutics.


1: Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of
HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. doi:
10.1021/acschembio.9b00292. Epub 2019 Jul 2. PubMed PMID: 31264832.