Linperlisib HCl
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MedKoo CAT#: 207110

CAS#: Unknown (HCl)

Description: Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. YY-20394 significantly inhibited primary tumor growth in immune-competent mice with 4T1 and CT26 tumors, as well as 4T1 lung metastasis with dose dependency. YY-20394 significantly inhibited T cell differentiation into Treg both in mouse splenocyte and in human primary CD4+ T cells, and was especially potent inhibiting their IL-10 secretion in vitro.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1650 2 Weeks
200mg USD 2050 2 Weeks
500mg USD 2950 2 Weeks
1g USD 3950 2 Weeks
2g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

Linperlisib HCl, purity > 98%, is in stock. Current shipping out time is about 3 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 207110
Name: Linperlisib HCl
CAS#: Unknown (HCl)
Chemical Formula: C28H38ClFN6O5S
Exact Mass: 588.253
Molecular Weight: 625.16
Elemental Analysis: C, 53.80; H, 6.13; Cl, 5.67; F, 3.04; N, 13.44; O, 12.80; S, 5.13


Related CAS #: 1702816-75-8 (free base)  

Synonym: YY-20394; YY 20394; YY20394; PI3Kδ-IN-2; Linperlisib HCl

IUPAC/Chemical Name: Methanesulfonamide, N-(5-(6-fluoro-8-((4-(1-hydroxy-1-methylethyl)-1-piperidinyl)methyl)-2-(4-morpholinyl)-4-quinazolinyl)-2-methoxy-3-pyridinyl)- hydrochloride

InChi Key: MAALREJFPYCTBJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H37FN6O5S.ClH/c1-28(2,36)20-5-7-34(8-6-20)17-19-13-21(29)15-22-24(31-27(32-25(19)22)35-9-11-40-12-10-35)18-14-23(33-41(4,37)38)26(39-3)30-16-18;/h13-16,20,33,36H,5-12,17H2,1-4H3;1H

SMILES Code: CS(=O)(NC1=CC(C2=C3C=C(F)C=C(CN4CCC(C(C)(O)C)CC4)C3=NC(N5CCOCC5)=N2)=CN=C1OC)=O.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001