WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 471030
CAS#: Unknown
Description: NED3238 is new highly potent inhibitor of arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively.
MedKoo Cat#: 471030
Name: NED3238 (HCl)
CAS#: Unknown
Chemical Formula: C17H30BCl2N3O4
Exact Mass:
Molecular Weight: 422.154
Elemental Analysis: C, 48.37; H, 7.16; B, 2.56; Cl, 16.79; N, 9.95; O, 15.16
Synonym: NED3238, NED 3238, NED-3238
IUPAC/Chemical Name: (3R,4S)-3-amino-1-((S)-2-amino-3-phenylpropyl)-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid dihydrochloride
InChi Key: YLRFCKXLPZIAMP-DQZPFBHVSA-N
InChi Code: InChI=1S/C17H28BN3O4.2ClH/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23;;/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23);2*1H/t14-,15-,17-;;/m0../s1
SMILES Code: O=C([C@]1(N)CN(C[C@@H](N)CC2=CC=CC=C2)C[C@@H]1CCCB(O)O)O.[H]Cl.[H]Cl
1. Van Zandt MC, et al. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II. J Med Chem. 2019 Aug 23.