WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573902
Description: L-2-Aminosuberic acid is a biochemical.
MedKoo Cat#: 573902
Name: L-2-Aminosuberic acid
Chemical Formula: C8H15NO4
Exact Mass: 189.1001
Molecular Weight: 189.211
Elemental Analysis: C, 50.78; H, 7.99; N, 7.40; O, 33.82
Synonym: (S)-2-Aminooctanedioic acid, Aminosuberic acid, L-2-Aminosuberic acid
IUPAC/Chemical Name: (S)-2-Aminooctanedioic acid
InChi Key: YOFPFYYTUIARDI-LURJTMIESA-N
InChi Code: 1S/C8H15NO4/c9-6(8(12)13)4-2-1-3-5-7(10)11/h6H,1-5,9H2,(H,10,11)(H,12,13)/t6-/m0/s1
SMILES Code: C(=O)([C@@H](N)CCCCCC(=O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
|Biological target:||L-2-Aminosuberic acid is a biochemical.|
|In vitro activity:||TBD|
|In vivo activity:||TBD|
The following data is based on the product molecular weight 189.211 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
|In vitro protocol:||TBD|
|In vivo protocol:||TBD|
1: Čolović M, Rousseau E, Zhang Z, Lau J, Zhang C, Kuo HT, Yang H, Schaffer P, François Bénard, Lin KS. Synthesis and evaluation of an (18)F-labeled boramino acid analog of aminosuberic acid for PET imaging of the antiporter system x(C)<sup/>. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3579-3584. doi: 10.1016/j.bmcl.2018.06.014. Epub 2018 Jun 8. PubMed PMID: 30316632.
2: Webster JM, Morton CA, Johnson BF, Yang H, Rishel MJ, Lee BD, Miao Q, Pabba C, Yapp DT, Schaffer P. Functional imaging of oxidative stress with a novel PET imaging agent, 18F-5-fluoro-L-aminosuberic acid. J Nucl Med. 2014 Apr;55(4):657-64. doi: 10.2967/jnumed.113.126664. Epub 2014 Feb 27. PubMed PMID: 24578242; PubMed Central PMCID: PMC4009729.
3: Kahnberg P, Lucke AJ, Glenn MP, Boyle GM, Tyndall JD, Parsons PG, Fairlie DP. Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid. J Med Chem. 2006 Dec 28;49(26):7611-22. PubMed PMID: 17181145.