WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558742
CAS#: 1702816-75-8 (free base)
Description: Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. YY-20394 significantly inhibited primary tumor growth in immune-competent mice with 4T1 and CT26 tumors, as well as 4T1 lung metastasis with dose dependency. YY-20394 significantly inhibited T cell differentiation into Treg both in mouse splenocyte and in human primary CD4+ T cells, and was especially potent inhibiting their IL-10 secretion in vitro.
MedKoo Cat#: 558742
Name: Linperlisib free base
CAS#: 1702816-75-8 (free base)
Chemical Formula: C28H37FN6O5S
Exact Mass: 588.253
Molecular Weight: 588.7
Elemental Analysis: C, 57.13; H, 6.34; F, 3.23; N, 14.28; O, 13.59; S, 5.45
Related CAS #: 1702816-75-8 (free base)
Synonym: Linperlisib; YY-20394; YY 20394; YY20394; PI3Kδ-IN-2;
IUPAC/Chemical Name: N-{5-[6-fluoro-8-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-2-(morpholin-4-yl)quinazolin-4-yl]-2-methoxypyridin-3-yl}methanesulfonamide
InChi Key: NVWKNQGHVMMAJW-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H37FN6O5S/c1-28(2,36)20-5-7-34(8-6-20)17-19-13-21(29)15-22-24(31-27(32-25(19)22)35-9-11-40-12-10-35)18-14-23(33-41(4,37)38)26(39-3)30-16-18/h13-16,20,33,36H,5-12,17H2,1-4H3
SMILES Code: CS(=O)(NC1=CC(C2=C3C=C(F)C=C(CN4CCC(C(C)(O)C)CC4)C3=NC(N5CCOCC5)=N2)=CN=C1OC)=O
