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SB-297006
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555605

CAS#: 58816-69-6

Description: SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM).


Price and Availability

Size Price Shipping out time Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2150 2 Weeks
2g USD 3950 2 Weeks
5g USD 5650 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-24. Prices are subject to change without notice.

SB-297006, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555605
Name: SB-297006
CAS#: 58816-69-6
Chemical Formula: C18H18N2O5
Exact Mass: 342.1216
Molecular Weight: 342.351
Elemental Analysis: C, 63.15; H, 5.30; N, 8.18; O, 23.37


Synonym: SB-297006; SB 297006; SB297006;

IUPAC/Chemical Name: N-benzoyl-4-nitro-L-phenylalanine, ethyl ester

InChi Key: BEZXGSZPWXRHIN-INIZCTEOSA-N

InChi Code: InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1

SMILES Code: O=C(OCC)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=CC=CC=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kuse Y, Tsuruma K, Kanno Y, Shimazawa M, Hara H. CCR3 Is Associated with the
Death of a Photoreceptor Cell-line Induced by Light Exposure. Front Pharmacol.
2017 Apr 18;8:207. doi: 10.3389/fphar.2017.00207. eCollection 2017. PubMed PMID:
28458639; PubMed Central PMCID: PMC5394117.

2: Wang F, Baba N, Shen Y, Yamashita T, Tsuru E, Tsuda M, Maeda N, Sagara Y.
CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem
Cell Res Ther. 2017 Feb 7;8(1):26. doi: 10.1186/s13287-017-0474-9. PubMed PMID:
28173860; PubMed Central PMCID: PMC5297016.

3: Provost V, Larose MC, Langlois A, Rola-Pleszczynski M, Flamand N, Laviolette
M. CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of
asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2. J Leukoc Biol. 2013
Aug;94(2):213-22. doi: 10.1189/jlb.0212074. Epub 2013 Mar 26. PubMed PMID:
23532518.

4: Mori A, Ogawa K, Someya K, Kunori Y, Nagakubo D, Yoshie O, Kitamura F, Hiroi
T, Kaminuma O. Selective suppression of Th2-mediated airway eosinophil
infiltration by low-molecular weight CCR3 antagonists. Int Immunol. 2007
Aug;19(8):913-21. PubMed PMID: 17804691.

5: White JR, Lee JM, Dede K, Imburgia CS, Jurewicz AJ, Chan G, Fornwald JA,
Dhanak D, Christmann LT, Darcy MG, Widdowson KL, Foley JJ, Schmidt DB, Sarau HM.
Identification of potent, selective non-peptide CC chemokine receptor-3
antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic
protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov
24;275(47):36626-31. PubMed PMID: 10969084.