WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 532438

CAS#: 2581-34-2

Description: 4-Nitro-3-cresol is a bioactive chemical.

Chemical Structure

CAS# 2581-34-2

Theoretical Analysis

MedKoo Cat#: 532438
Name: 4-Nitro-3-cresol
CAS#: 2581-34-2
Chemical Formula: C7H7NO3
Exact Mass: 153.0426
Molecular Weight: 153.137
Elemental Analysis: C, 54.90; H, 4.61; N, 9.15; O, 31.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 4-Nitro-3-cresol

IUPAC/Chemical Name: 4-Nitro-3-cresol


InChi Code: InChI=1S/C7H7NO3/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,9H,1H3

SMILES Code: CC1=CC(O)=CC=C1[N+]([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 153.137 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Azadmehr F, Zarei K. Fabrication of an imprinted electrochemical sensor from
l-tyrosine, 3-methyl-4-nitrophenol and gold nanoparticles for quinine
determination. Bioelectrochemistry. 2019 Jun;127:59-67. doi:
10.1016/j.bioelechem.2019.01.001. Epub 2019 Jan 18. PubMed PMID: 30703737.

2: Han Y, Zhang S, Wang Z, Zhang L, Zhang F, Sun F, Zhang H, Yuan Z, Zhang C,
Weng Q. Toxicological effects of 3-methyl-4-nitrophenol on mouse ovarian and
testicular cell proliferation, apoptosis and oocyte maturation. Reprod Toxicol.
2018 Dec;82:94-102. doi: 10.1016/j.reprotox.2018.10.005. Epub 2018 Oct 21. PubMed
PMID: 30352283.

3: Takeo M, Yamamoto K, Sonoyama M, Miyanaga K, Kanbara N, Honda K, Kato DI,
Negoro S. Characterization of the 3-methyl-4-nitrophenol degradation pathway and
genes of Pseudomonas sp. strain TSN1. J Biosci Bioeng. 2018 Sep;126(3):355-362.
doi: 10.1016/j.jbiosc.2018.04.001. Epub 2018 Apr 24. PubMed PMID: 29699943.

4: An YF, Geng XR, Mo LH, Liu JQ, Yang LT, Zhang XW, Liu ZG, Zhao CQ, Yang PC.
The 3-methyl-4-nitrophenol (PNMC) compromises airway epithelial barrier function.
Toxicology. 2018 Feb 15;395:9-14. doi: 10.1016/j.tox.2018.01.001. Epub 2018 Jan
4. PubMed PMID: 29307546.

5: Matsushita T, Honda S, Kuriyama T, Fujita Y, Kondo T, Matsui Y, Shirasaki N,
Takanashi H, Kameya T. Identification of mutagenic transformation products
generated during oxidation of 3-methyl-4-nitrophenol solutions by orbitrap tandem
mass spectrometry and quantitative structure-activity relationship analyses.
Water Res. 2018 Feb 1;129:347-356. doi: 10.1016/j.watres.2017.11.033. Epub 2017
Nov 14. PubMed PMID: 29169108.

6: Min J, Wang B, Hu X. Effect of inoculation of Burkholderia sp. strain SJ98 on
bacterial community dynamics and para-nitrophenol, 3-methyl-4-nitrophenol, and
2-chloro-4-nitrophenol degradation in soil. Sci Rep. 2017 Jul 20;7(1):5983. doi:
10.1038/s41598-017-06436-0. PubMed PMID: 28729667; PubMed Central PMCID:

7: Yang L, Ma S, Han Y, Wang Y, Guo Y, Weng Q, Xu M. Walnut Polyphenol Extract
Attenuates Immunotoxicity Induced by 4-Pentylphenol and 3-methyl-4-nitrophenol in
Murine Splenic Lymphocyte. Nutrients. 2016 May 12;8(5). pii: E287. doi:
10.3390/nu8050287. PubMed PMID: 27187455; PubMed Central PMCID: PMC4882700.

8: Yang L, Ma S, Wan Y, Duan S, Ye S, Du S, Ruan X, Sheng X, Weng Q, Taya K, Xu
M. In vitro effect of 4-pentylphenol and 3-methyl-4-nitrophenol on murine splenic
lymphocyte populations and cytokine/granzyme production. J Immunotoxicol. 2016
Jul;13(4):548-56. doi: 10.3109/1547691X.2016.1140853. Epub 2016 Mar 31. PubMed
PMID: 27031367.

9: Bu TL, Jia YD, Lin JX, Mi YL, Zhang CQ. Alleviative effect of quercetin on
germ cells intoxicated by 3-methyl-4-nitrophenol from diesel exhaust particles. J
Zhejiang Univ Sci B. 2012 Apr;13(4):318-26. doi: 10.1631/jzus.B1100318. PubMed
PMID: 22467373; PubMed Central PMCID: PMC3323946.

10: Okamura A, Saito I, Ueyama J, Ito Y, Nakajima T, Kamijima M. New analytical
method for sensitive quantification of urinary 3-methyl-4-nitrophenol to assess
fenitrothion exposure in general population and occupational sprayers. Toxicol
Lett. 2012 Apr 25;210(2):220-4. doi: 10.1016/j.toxlet.2011.10.008. Epub 2011 Oct
17. PubMed PMID: 22027349.

11: Herrero-Hernández E, Carabias-Martínez R, Rodríguez-Gonzalo E. Behavior of
phenols and phenoxyacids on a bisphenol-A imprinted polymer. Application for
selective solid-phase extraction from water and urine samples. Int J Mol Sci.
2011;12(5):3322-39. doi: 10.3390/ijms12053322. Epub 2011 May 20. PubMed PMID:
21686187; PubMed Central PMCID: PMC3116193.

12: Yue Z, She R, Bao H, Li W, Wang D, Zhu J, Chang L, Yu P. Exposure to
3-methyl-4-nitrophenol affects testicular morphology and induces spermatogenic
cell apoptosis in immature male rats. Res Vet Sci. 2011 Oct;91(2):261-8. doi:
10.1016/j.rvsc.2010.12.009. Epub 2011 Mar 26. PubMed PMID: 21440924.

13: Yue Z, She RP, Bao HH, Tian J, Yu P, Zhu J, Chang L, Ding Y, Sun Q. Necrosis
and apoptosis of renal tubular epithelial cells in rats exposed to
3-methyl-4-nitrophenol. Environ Toxicol. 2012 Nov;27(11):653-61. doi:
10.1002/tox.20688. Epub 2011 Mar 3. PubMed PMID: 21374789.

14: Li Q, Kobayashi M, Inagaki H, Hirata Y, Sato S, Ishizaki M, Okamura A, Wang
D, Nakajima T, Kamijima M, Kawada T. Effect of oral exposure to fenitrothion and
3-methyl-4-nitrophenol on splenic cell populations and histopathological
alterations in spleen in Wistar rats. Hum Exp Toxicol. 2011 Jul;30(7):665-74.
doi: 10.1177/0960327110377525. Epub 2010 Jul 12. PubMed PMID: 20624788.

15: Ganranoo L, Mishra SK, Azad AK, Shigihara A, Dasgupta PK, Breitbach ZS,
Armstrong DW, Grudpan K, Rappenglueck B. Measurement of nitrophenols in rain and
air by two-dimensional liquid chromatography-chemically active liquid core
waveguide spectrometry. Anal Chem. 2010 Jul 1;82(13):5838-43. doi:
10.1021/ac101015y. PubMed PMID: 20518471.

16: Li X, Li C, Suzuki AK, Watanabe G, Taneda S, Taya K. Endocrine disruptive
effect of 3-methyl-4-nitrophenol isolated from diesel exhaust particles in
Hershberger assay using castrated immature rats. Biosci Biotechnol Biochem. 2009
Sep;73(9):2018-21. Epub 2009 Sep 7. PubMed PMID: 19734673.

17: Mi Y, Zhang C, Li C, Taneda S, Watanabe G, Suzuki AK, Taya K. Quercetin
protects embryonic chicken spermatogonial cells from oxidative damage intoxicated
with 3-methyl-4-nitrophenol in primary culture. Toxicol Lett. 2009 Oct
8;190(1):61-5. doi: 10.1016/j.toxlet.2009.07.002. Epub 2009 Jul 9. PubMed PMID:

18: Li C, Suzuki AK, Takahashi S, Taneda S, Watanabe G, Taya K. Effects of
3-methyl-4-nitrophenol on the reproductive toxicity in female Japanese quail
(Coturnix japonica). Biol Pharm Bull. 2008 Nov;31(11):2158-61. PubMed PMID:

19: Galeano-Díaz T, Guiberteau-Cabanillas A, Espinosa-Mansilla A, López-Soto MD.
Adsorptive stripping square wave voltammetry (Ad-SSWV) accomplished with
second-order multivariate calibration determination of fenitrothion and its
metabolites in river water samples. Anal Chim Acta. 2008 Jun 23;618(2):131-9.
doi: 10.1016/j.aca.2008.04.058. Epub 2008 May 3. PubMed PMID: 18513534.

20: Furuta C, Suzuki AK, Watanabe G, Li C, Taneda S, Taya K. Nitrophenols
isolated from diesel exhaust particles promote the growth of MCF-7 breast
adenocarcinoma cells. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):320-6. doi:
10.1016/j.taap.2008.02.027. Epub 2008 Mar 10. PubMed PMID: 18439640.